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Colon pp 79-101 | Cite as

Immunology of the Colon

  • D. P. Jewell
  • W. S. Selby
Part of the Topics in Gastroenterology book series (TGEN)

Abstract

The colon provides an enormous reservoir of antigenic material — bacterial antigens, dietary proteins and polypeptides, and self-antigens from shed epithelial cells. The majority of immunological studies, however, have concentrated on the small intestine as this is thought to be the major site of immune responsiveness to exogenous antigens. Nevertheless, there is much evidence to suggest that the colon is able to mount local immune responses to the normal gut flora. The following examples illustrate this point. Normal subjects are able to synthesize secretory IgA antibodies to a wide variety of commensal intestinal bacteria.1,2 In children with double-barreled colostomies, the introduction of polio virus into the isolated distal colon stimulates local specific IgA antibody production in addition to a systemic IgM and IgG response.3 Patients with shigella dysentery were shown by Davies4 to produce antibody to the infecting organism in their stool before an antibody response in serum could be detected. Finally, the colonic immune system may play an important role in the inhibition of pathogenic organisms in certain carrier states.5 The ability of the colon to respond to its contents is also shown by the fact that the colon of a fetal animal is virtually devoid of immune cells. The full complement of lymphoid and plasma cells only develops after birth in response to the colonization of the lumen by bacteria.

Keywords

Ulcerative Colitis Lamina Propria Colonic Mucosa Intraepithelial Lymphocyte Secretory Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McClelland DBL, Samson RR, Parkin DM, et al: Bacterial agglutination studies with secretory IgA prepared from human gastrointestinal secretions and colostrum. Gut 13:450–458, 1972.PubMedCrossRefGoogle Scholar
  2. 2.
    McClelland DBL: Bacterial and viral infections of the gastrointestinal tract, in Asquith P (ed): Immunology of the Gastrointestinal Tract. London, Churchill Livingstone, 1979, pp. 214–245.Google Scholar
  3. 3.
    Ogra PL, Karzon DT: Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with polio-vaccine. J Immunol 102:1423–1430, 1969.PubMedGoogle Scholar
  4. 4.
    Davies A: An investigation into the serological properties of dysentery stools. Lancet 2:1009–1012, 1922.CrossRefGoogle Scholar
  5. 5.
    Gorbach SL: Progress in gastroenterology: Intestinal microflora. Gastroenterology 60:1110–1129, 1971.PubMedGoogle Scholar
  6. 6.
    Tomasi TB, Tan EM, Soloman A, et al: Characteristics of an immune system common to certain external secretions. J Exp Med 121:101–124, 1965.PubMedCrossRefGoogle Scholar
  7. 7.
    Crabbe PA, Carbonara AO, Heremans JF: The normal human intestinal mucosa as a major source of plasma cells containing A-immunoglobulin. Lab Invest 14:235–248, 1965.PubMedGoogle Scholar
  8. 8.
    Crabbe PA, Heremans JF: The distribution of immunoglobulin-containing cells along the human gastrointestinal tract. Gastroenterology 51:305–316, 1966.PubMedGoogle Scholar
  9. 9.
    Søltoft J, Søeberg B: Immunoglobulin-containing cells in the small intestine during acute enteritis. Gut 14:535–538, 1972.CrossRefGoogle Scholar
  10. 10.
    Gasbarrini G, Migliof, Serra MA, et al: Immunoglobulin studies of the jejunal mucosa in normal subjects and adult coeliac patients. Digestion 10:122–128, 1974.PubMedCrossRefGoogle Scholar
  11. 11.
    Brandtzaeg P, Baklien K: Immunohistochemical studies of the formation and epithelial transport of immunoglobulins in normal and diseased human intestinal mucosa. Scand J Gastroenterol, (suppl) 36:1–45, 1976.Google Scholar
  12. 12.
    Persson S, Danielsson D: Studies on Crohn’s disease. II. Immunoglobulin-containing cells in the terminal ileum. Acta Chir Scand 139:735–738, 1973.PubMedGoogle Scholar
  13. 13.
    Gebbers JO, Otto HF: Evidence for local immune complexes in ulcerative colitis. Acta Gastroenterol Belg 51:329–350, 1978.Google Scholar
  14. 14.
    Gelzayd EA, Kraft SC, Kirsner JB: Distribution of immunoglobulins in human rectal mucosa. I. Normal control subjects. Gastroenterology 54:334–340, 1968.PubMedGoogle Scholar
  15. 15.
    Søltoft J, Binder V, Gudmand-Höyer E: Intestinal immunoglobulins in ulcerative colitis. Scand J Gastroenterol 8:293–300, 1973.PubMedCrossRefGoogle Scholar
  16. 16.
    Skinner JM, Whitehead R: The plasma cells in inflammatory disease of the colon: A quantitative study. J Clin Pathol 27:643–646, 1974.PubMedCrossRefGoogle Scholar
  17. 17.
    Savilahti E: Workshop on secretory immunoglobulins, in Brent L, Holborow J (eds): Progress in Immunology, Amsterdam, North-Holland Publishing Co, 1974, vol 1, pp 238–243.Google Scholar
  18. 18.
    Brandtzaeg P: Mucosal and glandular distribution of immunoglobulin components. Immunohistochemistry with a cold ethanol-fixation technique. Immunology 26:1101–1114, 1974.PubMedGoogle Scholar
  19. 19.
    Brown WR, Borthistle BK, Chen ST: Immunoglobulin E (IgE) and IgE-containing cells in human gastrointestinal fluids and tissues. Clin Exp Immunol 20:227–237, 1975.PubMedGoogle Scholar
  20. 20.
    Tada T, Ishizaka K: Distribution of E-forming cells in lymphoid tissues of the human and monkey. J Immunol 104:377–387, 1970.PubMedGoogle Scholar
  21. 21.
    O’Donoghue DP, Kumar P: Rectal IgE cells in inflammatory bowel disease. Gut 20:149–153, 1979.PubMedCrossRefGoogle Scholar
  22. 22.
    Baklien K, Brandtzaeg P: Comparative mapping of the local distribution of immunoglobulin containing cells in ulcerative colitis and Crohn’s disease. Clin Exp Immunol 22:197–209, 1975.PubMedGoogle Scholar
  23. 23.
    Heatley RV, Rhodes J, Calcraft BJ et al: Immunoglobulin E in rectal mucosa of patients with proctitis. Lancet 2:1010–1012, 1975.PubMedCrossRefGoogle Scholar
  24. 24.
    Tomasi TB, Grey HM: Structure and function of immunoglobulin A. Progr Allergy 16:81–213, 1972.Google Scholar
  25. 25.
    Halpern MS, Koshland MR: Novel subunit in secretory IgA. Nature (London) 228:1276–1278, 1970.CrossRefGoogle Scholar
  26. 26.
    Brandtzaeg P: Mucosal and glandular distribution of immunoglobulin components: Differential localization of free and bound SC in secretory epithelial cells. J Immunol 112:1553–1559, 1974.PubMedGoogle Scholar
  27. 27.
    Poger ME, Lamm ME: Localization of free and bound secretory component in human intestinal epithelial cells. A model for the assembly of secretory IgA. J Exp Med 139:629–642, 1974.PubMedCrossRefGoogle Scholar
  28. 28.
    Brown WR, Isobe Y, Nakane P: Studies on translocation of immunoglobulins across intestinal epithelium. II. Immuno-electron-microscopic localization of immunoglobulins and secretory component in human intestinal mucosa. Gastroenterology 71:985–995, 1976.PubMedGoogle Scholar
  29. 29.
    Brandtzaeg P: Complex formation between secretory component and human immunoglobulins related to their content of J chain. Scand J Immunol 5:411–419, 1976.PubMedCrossRefGoogle Scholar
  30. 30.
    Tomasi TB, Betrsinenstock J: Secretory immunoglobulins, in Dixon FJ, Kunkel HG (eds): Advances in Immunology. New York, Academic Press Inc, 1968, vol 9, pp 1–96.Google Scholar
  31. 31.
    Mestecky J, Zikan J, Butler WT: Immunoglobulin M and secretory immunoglobulin A: Presence of a common polypeptide chain different from light chains. Science 171:1163–1165, 1971.PubMedCrossRefGoogle Scholar
  32. 32.
    Brandtzaeg P: Polymeric IgA is complexed with secretory component (S.C.) on the surface of human intestinal epithelial cells. Scand J Gastroenterol 8:39–52, 1978.Google Scholar
  33. 33.
    Brandtzaeg P: Two types of IgA immunocytes in man. Nature (London) New Biol 243:142–143, 1973.Google Scholar
  34. 34.
    Fichtelius KE: The gut epithelium: A first level lymphoid organ? Exp Cell Res 49:87–104, 1968.PubMedCrossRefGoogle Scholar
  35. 35.
    Donnellan WL: The structure of the colonic mucosa. The epithelium and subepithelial reticulohistiocytic complex. Gastroenterology 49:496–514, 1965.PubMedGoogle Scholar
  36. 36.
    Collan Y: Characteristics of non-epithelial cells in the epithelium of normal rat ileum. A light and electron microscopical study. Scand J Gastroenterol 7(suppl) 18:1–66, 1972.Google Scholar
  37. 37.
    Rudzik O, Beinenstock J: Isolation and characteristics of gut mucosal lymphocytes. Lab Invest 30:260–266, 1974.PubMedGoogle Scholar
  38. 38.
    Röpke C, Everett NB: Kinetics of intraepithelial lymphocytes in the small intestine of thymus deprived mice and antigen-deprived mice. Anat Rec 185:101–108, 1976.PubMedCrossRefGoogle Scholar
  39. 39.
    Fichtelius E, Yunis EJ, Good RA: Occurrence of lymphocytes within the gut epithelium of normal and neonatally thymectomized mice. Proc Soc Exp Biol Med 128:185–188, 1968.PubMedGoogle Scholar
  40. 40.
    Ferguson A, Parrott DMV: The effect of antigen deprivation on thymus-independent lymphocytes in the small intestine of the mouse. Clin Exp Immunol 12:477–488, 1972.PubMedGoogle Scholar
  41. 41.
    Guy-Grand D, Griscelli G, Vassalli P: The gut associated lymphoid system: Nature and properties of the large dividing cells. Eur J Immunol 4:435–443, 1974.PubMedCrossRefGoogle Scholar
  42. 42.
    Guy-Grand D, Griscelli G, Vassali P: The mouse gut T lymphocyte, a novel type of T-cell. Nature, origin and traffic in mice in normal and graft-versus-host conditions. J Exp Med 148:1661–1677, 1978.PubMedCrossRefGoogle Scholar
  43. 43.
    Arnaud-Battandier F, Bundy BM, O’Neill M, et al: Cytotoxic activities of gut mucosal lymphoid cells in guinea pigs. J Immunol 121:1059–1065, 1978.PubMedGoogle Scholar
  44. 44.
    Strickland RG, Husby G, Black WC, et al: Peripheral blood and intestinal lymphocyte sub-populations in Crohn’s disease. Gut 16:847–853, 1975.PubMedCrossRefGoogle Scholar
  45. 45.
    Meuwissen SGM, Feltkamp-Vroom TM, Brutel de la Riviere, et al: Analysis of the lymphoplasmacytic infiltrate in Crohn’s disease with special reference to identification of lymphocytesubpopulations, Gut 17:770–780, 1976.PubMedCrossRefGoogle Scholar
  46. 46.
    Selby WS, Janossy G, Jewell DP: Immunological characterization of intraepithelial lymphocytes of the human gastrointestinal tract. Gut 22: 169–176, 1981.PubMedCrossRefGoogle Scholar
  47. 47.
    Selby WS, Janossy G, Goldstein G, et al: T lymphocyte subsets in normal human intestinal mucosa— The distribution and relationship to MHC-derived antigens. Clin Exp Immunol 44:453–458, 1981.PubMedGoogle Scholar
  48. 48.
    Toner PG, Ferguson A: Intraepithelial cells in the human intestinal mucosa. J Ultrastruct Res 34:329–344, 1971.PubMedCrossRefGoogle Scholar
  49. 49.
    Meader RD, Landers DF: Electron and light microscopic observations on relationships between lymphocytes and intestinal epithelium. Am J Anat 121:763–774, 1967.PubMedCrossRefGoogle Scholar
  50. 50.
    Sprent J, Miller JFAP: Interaction of thymus lymphocytes with histocompatible cells. II. Recirculating lymphocytes derived from antigen-activated thymus cells. Cell Immunol 3:385–404, 1972.PubMedCrossRefGoogle Scholar
  51. 51.
    Bull DM, Bookman MA: Isolation and functional characterization of human intestinal mucosal lymphoid cells. J Clin Invest 59:966–974, 1977.PubMedCrossRefGoogle Scholar
  52. 52.
    Bookman MA, Bull DM: Characteristics of isolated intestinal mucosal lymphoid cells in inflammatory bowel disease. Gastroenterology 77: 503–510, 1979.PubMedGoogle Scholar
  53. 53.
    Bland PW, Richens ER, Britton DC, et al: Isolation and purification of human large bowel mucosal lymphoid cells: Effect of separation technique on functional characteristics. Gut 20:1037–1046, 1979.PubMedCrossRefGoogle Scholar
  54. 54.
    Fiocchi C, Battisto JR, Farmer RG: Gut mucosal lymphocytes in inflammatory bowel disease. Isolation and preliminary functional characterization. Dig Dis Sci 24:705–717, 1979.PubMedCrossRefGoogle Scholar
  55. 55.
    Chiba M, Shorter RG, Thayer WR, et al: K cell activity in lamina proprial lymphocytes from the human colon. Dig Dis Sci 24:817–822, 1979.PubMedCrossRefGoogle Scholar
  56. 56.
    Goodacre R, Davidson R, Singal D, et al: Morphological and functional characteristics of human intestinal lymphoid cells isolated by a mechanical means. Gastroenterology 76:300–308, 1979.PubMedGoogle Scholar
  57. 57.
    MacDermott RP, Franklin GO, Jenkins KM, et al: Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities. Gastroenterology 78:47–56, 1980.PubMedGoogle Scholar
  58. 58.
    Perlmann P, Broberger O: In vitro studies of ulcerative colitis. II. Cytotoxic action of white blood cells from patients on human fetal colon cells. J Exp Med 117:717–733, 1963.PubMedCrossRefGoogle Scholar
  59. 59.
    Watson DW, Quigley A, Bolt RJ: The cytotoxicity of circulating lymphocytes from ulcerative colitis patients for human colon epithelial cells: Disease specificity and relationship to disease activity. Gastroenterology 50:886–887, 1966.Google Scholar
  60. 60.
    Shorter RG, Cardoza M, Huizenga KA, et al: Further studies on in vitro cytotoxicity of lymphocytes for colonic epithelial cells. Gastroenterology 57:30–35, 1969.PubMedGoogle Scholar
  61. 61.
    Stobo JD, Tomasi TB, Huizenga KA, et al: In vitro studies of inflammatory bowel disease. Surface receptors of the mononuclear cell required to lyse allogeneic colonic epithelial cells. Gastroenterology 70:171–176, 1976.PubMedGoogle Scholar
  62. 62.
    Clancy R, Pucci A: Absence of K cells in human gut mucosa. Gut 19:273–276, 1978.PubMedCrossRefGoogle Scholar
  63. 63.
    Jondal M, Pross H: Surface markers on human B and T lymphocytes. VI. Cytotoxicity against cell lines as a functional marker for lymphocyte subpopulations. Int. J Cancer 15:596–605, 1975.PubMedCrossRefGoogle Scholar
  64. 64.
    Gupta S: Natural killer cells—Immunologists fancy? Gastroenterology 78:865–866, 1980.PubMedGoogle Scholar
  65. 65.
    West WH, Boozer RD, Herberman RB: Low affinity E-rosette formation by the human K cell. J Immunol 120:90–94, 1978.PubMedGoogle Scholar
  66. 66.
    Gupta S, Fernandes G, Nair M, et al: Spontaneous and antibody dependent cytotoxicity by human T cell subpopulations. Proc Natl Acad Sci USA 75:5137–5141, 1978.PubMedCrossRefGoogle Scholar
  67. 67.
    Kall MA, Koren HS: Heterogeneity of human natural killer cell populations. Cell Immunol 40:58–68, 1978.PubMedCrossRefGoogle Scholar
  68. 68.
    de Landazuri MO, Silva A, Alvarez J, et al: Evidence that natural cytotoxicity and antibody-dependent cellular cytotoxicity are mediated in humans by the same effector cell populations. J Immunol 123:252–258, 1979.PubMedGoogle Scholar
  69. 69.
    Helms RA, Bull DM: Natural killer activity of human lymphocytes against colon cancer cells. Gastroenterology 78:738–744, 1980.PubMedGoogle Scholar
  70. 70.
    Sawicki W, Kucharczyk K, Szymanska K, et al: Lamina propria macrophages of intestine of the guinea pig. Possible role in phagocytosis of migrating cells. Gastroenterology 73:1340–1344, 1977.PubMedGoogle Scholar
  71. 71.
    Stuart AE: Macrophages of the alimentary tract, in Stuart AE (ed): The Reticuloendothelial System, Edinburgh, E & S Livingstone Ltd, 1970, pp 29–31.Google Scholar
  72. 72.
    Deane HW: Some electron microscopic observations on the lamina propria of the gut, with comments on the close association of macrophages, plasma cells and eosinophils. Anat Rec 149:453–474, 1964.PubMedCrossRefGoogle Scholar
  73. 73.
    Riisager PM: Eosinophil leukocytes in ulcerative colitis. Lancet 2:1008–1009, 1959.CrossRefGoogle Scholar
  74. 74.
    Riis P, Anthonisen P: Eosinophilia in peripheral blood and inflammatory exudate in non-specific proctocolitis. Acta Med Scand 175:85–89, 1964.PubMedCrossRefGoogle Scholar
  75. 75.
    Wright R, Truelove SC: Circulating and tissue eosinophils in ulcerative colitis. Am J Dig Dis 11:831–846, 1966.PubMedCrossRefGoogle Scholar
  76. 76.
    Dobbins WO, Tomasini JT, Emory LR: Electron and light microscopic identification of the mast cell of the gastrointestinal tract. Gastroenterology 56:268–279, 1969.PubMedGoogle Scholar
  77. 77.
    Miller HR: Immune reactions in mucous membranes. II. The differentiation of intestinal mast cells during helminth expulsion in the rat. Lab Invest 24:339–347, 1971.PubMedGoogle Scholar
  78. 78.
    McAuley RL, Sommers SC: Mast cells in non-specific ulcerative colitis. Am J Dig Dis 6:233–236, 1961.CrossRefGoogle Scholar
  79. 79.
    Lloyd G, Green FHY, Fox H, et al: Mast cells and immunoglobulin E in inflammatory bowel disease. Gut 16:861–866, 1975.PubMedCrossRefGoogle Scholar
  80. 80.
    Thompson H, Buchmann P: Mast cell population in rectal biopsies from patients with Crohn’s disease, in Pepys J, Edwards AM (eds): The Mast Cell. Tunbridge Wells,England, Pitman Medical, 1979, pp. 697–701.Google Scholar
  81. 81.
    Dvorak AM, Connell AB, Dickersin GR: Crohn’s disease: A scanning electron microscopy study. Human Pathol 10:165–177, 1979.CrossRefGoogle Scholar
  82. 82.
    Gowans JL, Knight EJ: The route of recirculation of lymphocytes in the rat. Proc R Soc Lond Ser B 159:257–282, 1964.CrossRefGoogle Scholar
  83. 83.
    Griscelli C, Vassalli P, McCluskey RT: The distribution of large dividing lymph node cells in syngeneic recipient rats after intravenous injection. J Exp Med 130:1427–1451, 1969.PubMedCrossRefGoogle Scholar
  84. 84.
    Hall JG, Smith ME: Homing of lymph-borne immunoblasts to the gut. Nature (London) 226:262–263, 1970.CrossRefGoogle Scholar
  85. 85.
    Parrott DMV, Ferguson A: Selective migration of lymphocytes within the mouse small intestine. immunology 26:571–588, 1974.PubMedGoogle Scholar
  86. 86.
    McWilliams M, Phillips-Quagliata JM, Lamm ME: Characteristics of mesenteric lymph node cells homing to gut-associated lymphoid tissue in syngeneic mice. J Immunol 115:54–58, 1975.PubMedGoogle Scholar
  87. 87.
    Bloom W, Fawcett DW (eds): A Textbook of Histology, ed 10. Philadelphia, WB Saunders Co, 1975, pp 670–671.Google Scholar
  88. 88.
    Waksman BH: The homing pattern of thymus-derived lymphocytes in calf and neonatal mouse Peyer’s patches. J Immunol 111:878–884, 1973.PubMedGoogle Scholar
  89. 89.
    Owen RL: Segmental uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer’s patches in the normal unobstructed mouse intestine: An ultrasound study. Gastroenterology 72:440–451, 1977.PubMedGoogle Scholar
  90. 90.
    Craig SW, Cebra JJ: Peyer’s patches: An enriched source of precursors for IgA-producing immunocytes in the rabbit. J Exp Med 134:188–200, 1971.PubMedCrossRefGoogle Scholar
  91. 91.
    Müller-Schoop JW, Good RA: Functional studies of Peyer’s patches: Evidence for their participation in intestinal immune responses. J Immunol 114:1757–1760, 1975.PubMedGoogle Scholar
  92. 92.
    Lamm ME: Cellular aspects of immunoglobulin A. Adv Immunol 22:223–240, 1976.PubMedCrossRefGoogle Scholar
  93. 93.
    Cooper GN, Thonard JC, Crosby RL, et al: Immunological responses in rats following antigenic stimulation of Peyer’s patches. II. Histological changes in germ-free animals. Aust J Exp Biol Med Sci 46:407–414, 1968.PubMedCrossRefGoogle Scholar
  94. 94.
    Pollard M, Sharon N: Responses of the Peyer’s patches in germ-free mice to antigenic stimulation. Infect Immun 2:96–100, 1970.PubMedGoogle Scholar
  95. 95.
    Ferguson A, Parrott DMV: Growth and development of “antigen-free ” grafts of fetal mouse intestine. J Pathol 106:95–101, 1972.PubMedCrossRefGoogle Scholar
  96. 96.
    Moore AR, Hall JG: Evidence for a primary association between immunoblasts and small gut. Nature (London) 239:161–162, 1972.CrossRefGoogle Scholar
  97. 97.
    Walker WA, Isselbacher KJ: Intestinal antibodies. N Engl J Med 297:767–773, 1977.PubMedCrossRefGoogle Scholar
  98. 98.
    Cantor H, Boyse EA: Regulation of cellular and humoral immune responses by T cell subclasses. Cold Spring Harbor Symp Quart Biol 41PEJ:23–32, 1977.CrossRefGoogle Scholar
  99. 99.
    McMichael A: HLA restriction of human cytotoxic T lymphocytes specific for influenza virus. Poor recognition of virus associated with HLA A2. J Exp Med 148:1458–1467, 1978.PubMedCrossRefGoogle Scholar
  100. 100.
    Lai A Fat RFM, McClelland DBL, Van Furth R: In vitro synthesis of immunoglobulins, secretory component, complement and lysozyme by human gastrointestinal tissues. I. Normal Tissues. Clin Exp Immunol 23:9–19, 1976.PubMedGoogle Scholar
  101. 101.
    Bull DM, Bienestock J, Tomasi TB: Studies on human intenstinal immunoglobulin A. Gastroenterology 60:370–380, 1971.PubMedGoogle Scholar
  102. 102.
    Oldham G, Platts-Mills TAE, Chalmers DM: A quantitative method for measuring in vitro synthesis of IgA and IgG by human rectal mucosa: Studies on normal controls and patients with hypogammaglobulinaemia. Immunology 37:661–668, 1979.PubMedGoogle Scholar
  103. 103.
    McClelland DBL, Shearman DJC, Lai A Fat RFM, et al: In vitro synthesis of immunoglobulins, secretory component complement and lysozyme by human gastrointestinal tissues. II. Pathological tissues. Clin Exp Immunol 23:20–27, 1976.PubMedGoogle Scholar
  104. 104.
    Colten HR, Gordon JM, Borsos T, et al: Synthesis of the first component of human complement in vitro. J Exp Med 128:595–604, 1968.PubMedCrossRefGoogle Scholar
  105. 105.
    Lai A Fat RFM, Van Furth R: In vitro synthesis of some complement components by lymphoid tissues and circulating leucocytes in man. Immunology 28:359–368, 1975.PubMedGoogle Scholar
  106. 106.
    Stetcher VJ, Thorbeck GJ: Sites of synthesis of serum proteins. III. Production of B1C and B1E and transferrin by primate and rodent cell lines. J Immunol 99:660–668, 1976.Google Scholar
  107. 107.
    Stetcher VJ, Thorbeck GJ: Sites of synthesis of serum proteins. I. Serum proteins produced by macrophages in vitro. J Immunol 99:643–652, 1967.Google Scholar
  108. 108.
    Whaley K: Biosynthesis of the complement components and the regulatory proteins of the alternative pathway by human peripheral blood monocytes. J Exp Med 151:501–516, 1980.PubMedCrossRefGoogle Scholar
  109. 109.
    Hodgson HJF, Potter BJ, Jewell DP: Humoral immune system in inflammatory bowel disease. I. Complement levels. Gut 18:749–753, 1977.PubMedCrossRefGoogle Scholar
  110. 110.
    Potter BJ, Brown DJC, Watson A, et al: The humoral immune system in inflammatory bowel disease. III. The role of complement inhibitors and immunoconglutinins. Gut 21:1030–1034, 1980.PubMedCrossRefGoogle Scholar
  111. 111.
    Coombs RRA, Gell PGH: Classification of allergic reactions responsible for clinical hypersensitivity and disease, in Gell PGH, Coombs RRA, Lachman PJ (eds): Clinical Aspects of Immunology, ed 3. Oxford, Blackwell Scientific Publications, 1975, p. 761.Google Scholar
  112. 112.
    Gray I, Walzer M: Studies in mucous membrane hypersensitiveness. III. The allergic reactions of the passively sensitized rectal mucous membrane. Am J Dis Nutr 4:707–711, 1938.Google Scholar
  113. 113.
    Gray I, Harten M, Walzer M: Studies in mucous membrane hypersensitiveness. IV. The allergic reaction in the passively sensitized mucous membrane of the ileum and colon in humans. Am Int Med 13:2050–2056, 1940.Google Scholar
  114. 114.
    Grayzel D, Walzer M: The pathology of the allergic reactions in the passively sensitized tissues of the Macacus Rhesus monkey. J Allergy 10:478–479, 1939.Google Scholar
  115. 115.
    Le Veen HH, Falk G, Schatman B: Experimental ulcerative colitis produced by anticolon sera. Am Surg 154:275–280, 1961.Google Scholar
  116. 116.
    Shean FC, Barker WF, Fonkalsrud EW: Studies on active and passive antibody induced colitis in the dog. Am J Surg 107:337–339, 1964.PubMedCrossRefGoogle Scholar
  117. 117.
    Callahan WC, Goldman RG, Vial AB: Auer phenomenon in colon sensitized mice. J Surg Res 3:395–403, 1963.PubMedCrossRefGoogle Scholar
  118. 118.
    Bicks RO, Walker RH: Immunologic “colitis” in dogs. Am J Dig Dis (n. s.) 7:574–584, 1962.CrossRefGoogle Scholar
  119. 119.
    Perlmann P, Hammarstrom S, Lagercrantz R, et al: Auto-antibodies to colon in rats and human ulcerative colitis: Cross-reactivity with Escherichia coli 014 antigen. Proc Soc Exp Biol 125:975–980, 1967.PubMedGoogle Scholar
  120. 120.
    Palou RO, Halpern B, Zweibaum A, et al: Experimental production of haemorrhagic ulcerative colitis with autoantibodies. Med Hyg 25:62–64, 1967.Google Scholar
  121. 121.
    Asherson GL, Holborrow EJ: Autoantibody production in rabbits. VII Autoantibodies to gut by the injection of bacteria. Immunology 10:161–167, 1966.PubMedGoogle Scholar
  122. 122.
    Cooke EM, Filipe MI, Dawson IMP: The production of colonic autoantibodies in rabbits by immunization with escherichia coli. J Pathol Bacteriol 96:125–130, 1968.PubMedCrossRefGoogle Scholar
  123. 123.
    Hausamen TU, Halcrow DA, Taylor KB: Biological effects of gastrointestinal antibodies. I. The production of antibodies to components of adult and fetal guinea pig gastric and colonic mucosa. Gastroenterology 56:1053–1061, 1969.PubMedGoogle Scholar
  124. 124.
    Goldgraber MB, Kirsner JB: The Arthus phenomenon in the colon of rabbits. A serial histological study. Arch Pathol 6:556–571, 1959.Google Scholar
  125. 125.
    Kirsner JB, Elchlepp JE, Goldgraber MB, et al: Production of an experimental ulcerative “colitis” in rabbits. Arch Pathol 68:392–408, 1959.PubMedGoogle Scholar
  126. 126.
    Hodgson HJF, Potter BJ, Skinner J, et al: Immune-complex mediated colitis in rabbits. Gut 19:225–232, 1978.PubMedCrossRefGoogle Scholar
  127. 127.
    Mee AS, McLaughlin JE, Hodgson HJF, et al: Chronic immune colitis in rabbits. Gut 20:1–5, 1979.PubMedCrossRefGoogle Scholar
  128. 128.
    Bicks RO, Rosenberg EW: A chronic delayed hypersensitivity reaction in the guinea pig colon. Gastroenterology 46:543–549, 1964.PubMedGoogle Scholar
  129. 129.
    Bicks RO, Azar MM, Rosenberg EW, et al: Delayed hypersensitivity reactions in the intestinal tract. I. Studies of 2,4-dinitrochlorobenzene-caused guinea pig and swine colon lesions. Gastroenterology 53:422–436, 1967.Google Scholar
  130. 130.
    Rabin BS, Rogers SJ: A cell-mediated immune model of inflammatory bowel disease in the rabbit. Gastroenterology 75:29–33, 1978.PubMedGoogle Scholar
  131. 131.
    Holden RJ, Ferguson A: Histopathology of cell mediated immune reaction in mouse colon-allograft rejection. Gut 17:661–670, 1976.PubMedCrossRefGoogle Scholar
  132. 132.
    Singer JB, Spiro HM, Thayer WR: Colonic manifestations of runt disease. Yale J Biol Med 39:106–112, 1966.PubMedGoogle Scholar
  133. 133.
    Skinner JM, Whitehead R: Immunological aspects of Gastrointestinal pathology. Curr Top Pathol 63:259–288, 1976.PubMedCrossRefGoogle Scholar
  134. 134.
    Bland PW, Britton DC, Richens ER, Pledger JV: Peripheral, mucosal, and tumour-infiltrating components of cellular immunity in cancer of the large bowel. Gut 22:744–751, 1981.PubMedCrossRefGoogle Scholar
  135. 135.
    Fiocchi C, Battisto JR, Farmer RG: Studies on isolated gut mucosal lymphocytes in inflammatory bowel disease. Detection of activated T cells and enhanced proliferation to staphylococcus aureus and lipopolysaccharides. Dig Dis Sci 26:728–736, 1981.PubMedCrossRefGoogle Scholar
  136. 136.
    Falchuk ZM, Barnhard E, Machado I: Human colonic mononuclear cells: studies of cytotoxic function. Gut 22:290–294, 1981.PubMedCrossRefGoogle Scholar
  137. 137.
    Goodacre RL, Bienenstock J: Reduced suppressor cell activity in intestinal lymphocytes from patients with Crohn’s disease. Gastroenterology 82:652–658, 1982.Google Scholar
  138. 138.
    Chiba M, Bartnick W, ReMine SG, Thayer WR, Shorter RG: Human colonic intraepithelial and lamina proprial lymphocytes: Cytotoxicity in vitro and the potential effects of the isolation method on their functional properties. Gut 22:177–186, 1981.PubMedCrossRefGoogle Scholar
  139. 139.
    MacDermott RP, Bragdon MF, Jenkins KM: Human intestinal mononuclear cells. II. Demonstration of a naturally occurring subclass of T cells which respond in the allogeneic mixed leukocyte reaction but do not effect cell mediated lympholysis. Gastroenterology 80:748–757, 1981.PubMedGoogle Scholar
  140. 140.
    Selby WS, Jewell DP: Intestinal T-cell function. Gastroenterology 82:167, 1982.PubMedGoogle Scholar
  141. 141.
    Selby WS, Poulter LW, Hobbs S, Jewell DP, Janossy G: Heterogeneity of HLA-DR-positive histiocytes in human intestinal lamina propria: A combined histochemical and immunohistological analysis. J Clin Path (in press).Google Scholar
  142. 142.
    MacDermott RP, Nash GS, Bertovich MJ, Seiden MV, Bragdon MJ, Beale MG. Alterations of IgM, IgG and IgA synthesis and secretion by peripheral blood and intestinal mononuclear cells from patients with ulcerative colitis and Crohn’s disease. Gastroenterology 81:844–852, 1981.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • D. P. Jewell
    • 1
  • W. S. Selby
    • 1
  1. 1.The John Radcliffe HospitalHeadingtonEngland

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