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Colon pp 275-292 | Cite as

Drugs and the Colon

  • R. Wanitschke
  • K. Ewe
Part of the Topics in Gastroenterology book series (TGEN)

Abstract

It is not our intention to review drug effects in the colon, which was done extensively and profoundly by Forth and Rummel1 and Powell.2 Our contribution will present studies of drug effects on physiological absorption and secretion processes obtained in the intact human colon and based on results of intestinal perfusion studies of the whole colon and measurements of transepithelial electrical potential difference (PD) in the rectosigmoid colon. These are at present the practiced and—regarding perfusion studies—most accurate techniques in the hands of clinicians to directly study drug effects on a local dose-response scale in the intact human colon. Since these methods are relatively new and their use practically limited to clinical research, no extensive data on this topic are yet available.

Keywords

Bile Acid Cardiac Glycoside Ricinoleic Acid Deoxycholic Acid Intestinal Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • R. Wanitschke
    • 1
  • K. Ewe
    • 1
  1. 1.I. Medizinische Klinik und PoliklinikUniversität MainzMainzFederal Republic of Germany

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