The Enterohepatic Circulation
The principal components of bile are the conjugated bile acids, cholesterol, and phospholipid, but in addition to these major components there is a vast array of minor components. Some of these are waste products of metabolism excreted by secretion in the bile, for example, bilirubin and the bile pigments. Many are dietary components that have been absorbed from the gut lumen by passive diffusion (because of their lipid solubility) and are detoxified by the liver and secreted in the bile. Some are functioning compounds that are not waste products but that are nevertheless biliary secreted, for example, the bile acids and a wide range of other steroid conjugates.
KeywordsBile Acid Terminal Ileum Enterohepatic Circulation Lithocholic Acid Active Transport Mechanism
Unable to display preview. Download preview PDF.
- 1.Paumgartner G: Physiology of bile secretion: Bile-acid dependent bile flow, in Bianchi L, Gerok W, Sickinger K (eds): Liver and Bile. Lancaster, England, MTP Press, 1977, pp 45–53.Google Scholar
- 2.Erlinger S: Bile acid-dependent secretion, in Bianchi L, Gerok W, Sickinger K, (eds): Liver and Bile. Lancaster, England, MTP Press Ltd, 1977, pp 55–62.Google Scholar
- 6.Smith RL: The Excretory Function of Bile. London, Chapman & Hall Ltd, 1973.Google Scholar
- 7.Williams RT: Detoxification Mechanisms. London, Chapman & Hall Ltd, 1959.Google Scholar
- 8.Milburn P, Smith RL, Williams RT: Biliary excretion of foreign compounds. Biphenyl, Stilbestrol and Phenolphthalein in the rat: Molecular weight, polarity and metabolism as factors in biliary excretion. Biochem J 105:1275–1281 (1967).Google Scholar
- 12.Hofmann AF, Poley JR: Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride. Gastoenterology 62:918–934, 1972.Google Scholar
- 13.Drasar BS, Hill MJ: Human Intestinal Flora. London, Academic Press Inc Ltd, 1974.Google Scholar
- 20.Hill MJ: Bile acid conservation, Fumagalli R, Kritchevsky D, Paoletti R (eds): Proceedings of the Seventh International Symposium on Drugs Affecting Lipid Metabolism. Amsterdam, Elsevier/North Holland, 1980, pp. 89–96.Google Scholar
- 24.Hofmann AF: The enterohepatic circulation of bile acids in man, in Paumgartner G (ed): Bile Acids Clinics on Gastroenterology. London, WB Saunders, 1977, pp 3–24.Google Scholar
- 35.Summerfield WHJ: Ammonia metabolism in the gastrointestinal tract. Progr Gastroenterol 2:276–287, 1969.Google Scholar