Ultrastructure of Amyloid Fibrils in Alzheimer’s Disease and Down’s Syndrome

  • Taihei Miyakawa
  • Shoichi Katsuragi
  • Kenjiro Watanabe


Ultrastructure of amyloid fibrils in senile plaques of the brains with Alzheimer’s disease and adult Down’s syndrome has not yet been reported in detail. In the present study, in addition to the electron microscopic examination of tissue specimens, replicas of amyloid fibrils made by a quick freezing method ( Heuser et al. 1979 ) were examined.


Prion Protein Senile Plaque Amyloid Fibril Scrapie Prion Protein Quantal Transmitter Release 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bookman JM, Kingsbury DT, McKinley MP and Prusiner SB (1985) Creutzfeldt-Jacob disease prion proteins in human brains. N Engl J Med 312:73–78CrossRefGoogle Scholar
  2. Cohen AS, Shirahama T and Skinner M (1982) Electron microscopy of amyloid, in “Electron Microscopy of Proteins vol. 3,” Hams JR (ed.) Academic Press, New York, pp 165–206Google Scholar
  3. De Armond SJ, McKinley MP, Barry RA, Braunfeld MB, McColloch JR and Prusiner SB (1985) Identification of prion amyloid filaments in scrapie-infected brain. Cell 41:221–235CrossRefGoogle Scholar
  4. Epstein CJ (1983) Down’s syndrome and Alzheimer’s disease:implications and approaches. In “Banbury Report 15; Biological Aspects of Alzheimer’s Disease” Katzman R (ed.) Cold Spring Harbor, New York, pp169–182Google Scholar
  5. Gajdusek DC (1977) Unconventional viruses and the origin and disappearance of kuru. Science 197:943–960CrossRefGoogle Scholar
  6. Glenner GG (1980) Amyloid deposits and amylodosis: the beta-fibrillosis. N Engl J Med 302:1283–1292, 1333-1334CrossRefGoogle Scholar
  7. Heuser JE, Reese TS, Dimmis MJ, Jan Y and Jan L (1979) Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release. J Cell Biol 81:275–300CrossRefGoogle Scholar
  8. Masters CL, Gajdusek DC and Gibbs GJ, Jr (1981) Creutzfeldt-Jacob disease virus isolations from the Gerstmann-Straussler syndrome. Brain 104:559–588CrossRefGoogle Scholar
  9. Miyakawa T, Shimoji A, Kuramoto R and Higuchi Y (1982) The relationship between senile plaques and cerebral blood vessels in Alzheimer’s disease and senile dementia. Virchows Archiv [Cell Pathol] 40:121–129CrossRefGoogle Scholar
  10. Miyakawa T, Katsuragi S, Watanabe K, Shimoji A and Ikeuchi Y (1986) Ultrastructural studies of amyloid fibrils and senile plaques in human brain. Acta Neuropathol (Berl) 70:202–208CrossRefGoogle Scholar
  11. Prusiner SB (1982) Novel proteinaceous infectious particles cause scrapie. Science 216:136–144CrossRefGoogle Scholar
  12. Prusiner SB, McKinley MP, Bowman KA, Bolton DC, Bendheim PE, Groth DF and Glenner GG (1983) Scpapie prions aggregate to form amyloid-like birefringent rods. Cell 35:349–358CrossRefGoogle Scholar
  13. Schlote W (1965) Polarisationen, optische und elektromikroskopische Beobachtungen bei “drusiger “ Degeneration der Hirngefasse im Senium, Proc 5th Int Congress Neuropathol, Zulch 490–494Google Scholar
  14. Terry RD, Gonatas NK and Weiss M (1964) Ultrastructural studies in Alzheimer’s presenile dementia. Am J Pathol 44:269–283Google Scholar
  15. Wisniewski H and Terry RD (1973) Reexamination of the pathogenesis the senile plaque. Prog Neuropathol 11:1–6Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Taihei Miyakawa
    • 1
  • Shoichi Katsuragi
    • 1
  • Kenjiro Watanabe
    • 1
  1. 1.Department of neuropsychiatryKumamoto University Medical SchoolHonjo-Machi, Kumamoto, 860Japan

Personalised recommendations