Ubiquitin: A Newly Identified Component of Paired Helical Filaments

  • Hiroshi Mori
  • Jun Kondo
  • Yasuo Ihara


The progressive accumulation of unusual fibers in neuronal perikarya and processes characterizes the brain affected with Alzheimer’s disease (AD). The fibers are composed of two 10 nm filaments wound into a helix with a half-periodicity of 80 nm and thus termed paired helical filaments (PHF)1.


Abnormal Protein Cyanogen Bromide Paired Helical Filament Neuronal Perikaryon Paired Helical Filament 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Hiroshi Mori
    • 1
  • Jun Kondo
    • 1
    • 2
  • Yasuo Ihara
    • 1
  1. 1.Tokyo Metropolitan Institute of GerontologyItabashiku Tokyo 173Japan
  2. 2.Mitsubishi Chemical Industries Limited Research CenterBiosciences LaboratoryKamoshida, Midoriku Yokohama 227Japan

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