Replacement of SAA from the HDL-SAA Complex by APO AI and APO AII: HDL has Higher Binding Capacity for SAA than for AA
When purified apo-AI or apo-AII was added to human SAA-HDL in vitro, some of the apoproteins were incorporated in the complexes. On the other hand, SAA was displaced from HDL. Apo A-II had a higher SAA “displacing activity” than apo-AI. We also observed that SAA had a higher binding affinity for HDL than protein AA. Essentially the same was observed when human apoprotein AII was added to mouse SAA-HDL. Our results also indicate that mouse SAA2 has lower affinity for HDL than SAA1.
KeywordsHigh Density Lipoprotein Amyloid Fibril Serum Amyloid Secondary Amyloidosis Small Intestinal Wall
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