Biochemical and Molecular Studies of Native and Synthetic B-Amyloid Protein in Alzheimer’s Disease
In contrast to many brain degenerative diseases, in which neuronal loss is unaccompanied by characteristic structural lesions in adjacent neurons that have not yet died, Alzheimer’s disease (AD) is marked by striking morphological changes in many remaining cells and their surrounding milieu. Despite doubts expressed over the years about the utility of analyzing the fibrous deposits in AD brain, it is increasingly apparent that molecular studies of these lesions can provide important insights into the pathogenesis of cortical degeneration in AD. Neuritic plaques, neurofibrillary tangles and amyloid angiopathy are the principal alterations that accompany AD. Although the term amyloid has often been used to refer to the fibrous deposits in all three of these lesions, the intraneuronal paired helical filaments (PHF) and antigenically related straight filaments found in neurofibrillary tangles (NFT) and in dystrophic neurites within senile plaques are structurally distinct from all other amyloid fibrils. This fact as well as the substantial available evidence that PHF and amyloid filaments In AD brain have different antigenic compositions makes it preferable not to apply the term amyloid to the intraneuronal fibers pending their full elucidation.
KeywordsSenile Plaque Neuritic Plaque Paired Helical Filament Aged Mammal Vascular Amyloid
Unable to display preview. Download preview PDF.
- 1.Selkoe DJ, Abraham C, Rasool CG. IV International Symposium on Amyloidosis. Harriman, New York, November 9–12, 1984.Google Scholar
- 8.Wisniewski HM, Johnson AB, Raine CS, Kay WJ, Terry RD. Lab Invest 287, 1987.Google Scholar
- 13.Robakis NI, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yao X-L, Ramakrishna N, Wolfe G, Silverman WP, Brown WT. Lancet i: 385, 1987.Google Scholar
- 17.Schweber M, Tuson C, Shiloh R, Ben Neriah Z. Neurol 37 (Suppl 1): 222 (Abstract).Google Scholar
- 18.Selkoe DJ, Galibert L, Podlisny M, Duffy LK. Soc Neurosci Abstr 12(1):35, 1986.Google Scholar
- 19.Abraham CR, Selkoe DJ, Potter H. Neurol 37 (Suppl l):330, 1987.Google Scholar
- 20.Selkoe DJ, Podlisny MB, Vickers E, Duffy LK. Neurology, April 1988 (in press).Google Scholar