Biochemical and Molecular Studies of Native and Synthetic B-Amyloid Protein in Alzheimer’s Disease

  • D. J. Selkoe
  • C. L. Joachim
  • M. B. Podlisny
  • G. Lee
  • L. K. Duffy


In contrast to many brain degenerative diseases, in which neuronal loss is unaccompanied by characteristic structural lesions in adjacent neurons that have not yet died, Alzheimer’s disease (AD) is marked by striking morphological changes in many remaining cells and their surrounding milieu. Despite doubts expressed over the years about the utility of analyzing the fibrous deposits in AD brain, it is increasingly apparent that molecular studies of these lesions can provide important insights into the pathogenesis of cortical degeneration in AD. Neuritic plaques, neurofibrillary tangles and amyloid angiopathy are the principal alterations that accompany AD. Although the term amyloid has often been used to refer to the fibrous deposits in all three of these lesions, the intraneuronal paired helical filaments (PHF) and antigenically related straight filaments found in neurofibrillary tangles (NFT) and in dystrophic neurites within senile plaques are structurally distinct from all other amyloid fibrils. This fact as well as the substantial available evidence that PHF and amyloid filaments In AD brain have different antigenic compositions makes it preferable not to apply the term amyloid to the intraneuronal fibers pending their full elucidation.


Senile Plaque Neuritic Plaque Paired Helical Filament Aged Mammal Vascular Amyloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • D. J. Selkoe
    • 1
    • 2
  • C. L. Joachim
    • 1
    • 2
  • M. B. Podlisny
    • 1
    • 2
  • G. Lee
    • 1
    • 2
  • L. K. Duffy
    • 1
    • 2
  1. 1.Department of Neurology (Neuroscience)Harvard Medical SchoolUSA
  2. 2.Center for Neurologic DiseasesBrigham and Women’s HospitalBostonUSA

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