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Noninvasive Evaluation of Left Ventricular Systolic and Diastolic Time Intervals in Familial Amyloid Polyneuropathy

  • Jun Kono
  • Minoru Hongo
  • Shinichi Okubo
  • Hiroyoshi Yamada
  • Takuo Misawa
  • Saori Iwanami
  • Osamu Kinoshita
  • Shozo Kusama
  • Shu-ichi Ikeda
Chapter

Abstract

To determine left ventricular (LV) systolic and diastolic properties in patients with familial amyloid polyneuropathy (FAP), we analyzed simultaneous recordings of the electrocardiogram, phonocardiogram, carotid arterial pulse, and apex cardiogram (ACG) in 13 patients and 20 normal subjects. The following variables were measured: (1) LV systolic time intervals = iso-volumic contraction time (ICT), corrected preejection period (PEPi), corrected ejection time (ETi), corrected Q-I interval (Q-Ii), corrected Q-II interval (Q-IIi), PEP/ET, and ICT/ETi; (2) 1EA-O interval (IIA-O) = the time interval from the onset of the aortic component of the second heart sound to the 0 point on the ACG; (3) ΔT = the time interval from the onset of the aortic component of the second heart sound to the point on the ACG down-stroke where the curve falls to 50% of the total height of the diastolic deflection; and (4) ΔT/IIA-O. Patients with FAP had significantly greater Q-Ii, PEPi, Q-IIi, and PEP/ET than normal subjects, whereas there were no differences in the ETi, ICT, and ICT/ETi. Patients with FAP also showed slightly greater IIA-O than normal subjects but the difference was not significant. In addition, AT and AT/IIA-0 were significantly greater in patients with FAP than in normal subjects. We conclude that in patients with FAP, LV relaxation is impaired, especialy in early diastole, whereas systolic function is generally preserved, and that electromechanical delay is markedly increased.

Keywords

Heart Sound Heart Catheterization Alized Amyloidosis Early Diastole Systolic Time Interval 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    B. O. Olofsson, P. Bjerle, and G. Osterman, Hemodynamic and angiocardiographic observations in familial amyloidosis with polyneuropathy, Acta Med Scand 212:77 (1982).CrossRefGoogle Scholar
  2. 2.
    C. Backman, and B. O. Olofsson, Echocardiographic features in familial amyloidosis with polyneuropathy, Acta Med Scand 214:273 (1983).CrossRefGoogle Scholar
  3. 3.
    M. Hongo, and S. Ikeda, Echocardiographic assessment of the evolution of amyloid heart disease: a study with familial amyloid polyneuropathy, Circulation 73:249 (1986).CrossRefGoogle Scholar
  4. 4.
    S. Ikeda, N. Hanyu, M. Hongo, J. Yoshioka, H. Oguchi, N. Yanagisawa, T. Kobayashi, H. Tsukagoshi, N. Ito, and T. Yokota, Hereditary generalized amyloidosis with polyneuropathy: clinicopathological study of 65 Japanese patients, Brain 110:315 (1986).CrossRefGoogle Scholar
  5. 5.
    A. M. Weissler, W. S. Harris, and C. D. Schoenfeld, Systolic time intervals in heart failure in man, Circulation 37:149 (1968).CrossRefGoogle Scholar
  6. 6.
    A. G. Wallace, J. H. Mitchell, N. S. Skinner, and S. J. Sarnoff, Duration of the phases of left ventricular systole, Circ Res 12:611 (1962).CrossRefGoogle Scholar
  7. 7.
    E. Coelho, and J. C. Pimentel, Cardiac involvement in a peculiar form of paramyloidosis, Am J Cardiol 8:624 (1961).CrossRefGoogle Scholar
  8. 8.
    P. A. Hofer, and R. Andersson, Postmortem findings in primary familial amyloidosis with polyneuropathy: a study based on six cases from Northern Sweden, Acta Pathol Microbiol Scand 83:309 (1975).Google Scholar
  9. 9.
    A. Okayama, T. Kumada, M. Ozaki, N. Sugihara, T. Yamagishi, H. Utsunomiya, T. Yorozu, M. Shibata, Y. Matsuda, and R. Kusukawa, Noninvasive evaluation of left ventricular relaxation by apexcardiogram in man, J Cardiogr 14 (Suppl. V):140 (1984).Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Jun Kono
    • 1
  • Minoru Hongo
    • 1
  • Shinichi Okubo
    • 1
  • Hiroyoshi Yamada
    • 1
  • Takuo Misawa
    • 1
  • Saori Iwanami
    • 1
  • Osamu Kinoshita
    • 1
  • Shozo Kusama
    • 1
  • Shu-ichi Ikeda
    • 2
  1. 1.The First Department of Internal MedicineShinshu University School of MedicineMatsumoto 390Japan
  2. 2.The Third Department of Internal MedicineShinshu University School of MedicineMatsumoto 390Japan

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