Impaired Left Ventricular Diastolic Properties in Patients with Familial Amyloid Polyneuropathy : A Study by Computerized M-Mode Echocardiography
To determine left ventricular (LV) diastolic properties in patients with familial amyloid polyneuropathy (FAP), we examined 17 patients by means of computerized M-mode echocardiography and compared the results with 25 normal subjects. Patients with FAP showed a significantly lower peak rate of diastolic LV internal dimension (dD/dt) as well as a lower peak rate of diastolic thinning of the LV posterior wall (dW/dt) than normal subjects, whereas LV systolic parameters, including cardiac index, ejection fraction, and ejection time, were nearly identical. Furthermore, although eight of the 17 patients had normal LV posterior wall thickness, they had a significantly lower dD/dt, as well as a lower dW/dt, than normal subjects. We conclude that in patients with FAP LV diastolic properties are changed, whereas systolic function is almost preserved, and diastolic abnormalities can be seen even in the absence of LV hypertrophy.
KeywordsLeft Ventricular Hypertrophy Cardiac Amyloidosis Ejection Time Systemic Amyloidosis Left Ventricular Dimension
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