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Genetic Study of Late-Onset in Hereditary Amyloid Neuropathy (HAN) — Type I (Portuguese, Andrade)

  • Luisa Lobato
  • Fernanda Teixeira
  • Alda Sousa
  • Jorge Sequeiros
Chapter

Abstract

Hereditary amyloid neuropathy (HAN) — type I has long been considered as a typically monomorphic disease, its clinical course and age of onset (usually third to fourth decades) showing relatively little variation. Nonetheless, Andrade1 refers to a small group of patients where onset was between 35 and 50 years of age. In a later report2 it was shown that onset was after age 40 in 12.5% of the cases; 26.1% of these belonged to kindreds where onset was exclusively or predominantly after that age.

Keywords

Genetic Counseling Genetic Modifier Late Onset Seventh Decade Familial Amyloid Polyneuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Luisa Lobato
    • 1
    • 2
  • Fernanda Teixeira
    • 2
    • 3
  • Alda Sousa
    • 3
  • Jorge Sequeiros
    • 1
    • 2
    • 3
  1. 1.Centro de Estudos da Paramiloidose (CEP)Universidade do PortoPortugal
  2. 2.Hospital Geral de Santo AntónioUniversidade do PortoPortugal
  3. 3.Instituto de Ciências Biomédicas de Abel SalazarUniversidade do PortoPortugal

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