Genetic Study of Late-Onset in Hereditary Amyloid Neuropathy (HAN) — Type I (Portuguese, Andrade)
Hereditary amyloid neuropathy (HAN) — type I has long been considered as a typically monomorphic disease, its clinical course and age of onset (usually third to fourth decades) showing relatively little variation. Nonetheless, Andrade1 refers to a small group of patients where onset was between 35 and 50 years of age. In a later report2 it was shown that onset was after age 40 in 12.5% of the cases; 26.1% of these belonged to kindreds where onset was exclusively or predominantly after that age.
KeywordsGenetic Counseling Genetic Modifier Late Onset Seventh Decade Familial Amyloid Polyneuropathy
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