Is the Homozygous State for Hereditary Amyloid Neuropathy (HAN) — Type I (Portuguese, Andrade) Incompatible with Early Intrauterine Life?

  • Jorge Sequeiros
  • Alda Sousa


In a classic definition, an autosomal dominant trait was one that would show the same effect in either the homozygous, or the heterozygous state; nevertheless, experience has been accumulating in medical genetics of a number of autosomal dominant disorders where a dose effect in homozygosity is suspected 1–6, including the Finnish type of hereditary amyloid neuropathy (HAN — type IV)7.


Marfan Syndrome Autosomal Dominant Disorder Autosomal Dominant Trait Familial Amyloidotic Polyneuropathy Unaffected Child 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Jorge Sequeiros
    • 1
    • 2
    • 3
  • Alda Sousa
    • 3
  1. 1.Centro de Estudos da Paramiloidose AntónioPortugal
  2. 2.Hospital Geral de Santo AntónioPortugal
  3. 3.Instituto de Ciências Biomédicas de Abel SalazarUniversidade do PortoPortugal

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