Familial Amyloidotic Polyneuropathy in Sweden — RFLP Analysis in Patients and in Healthy Controls
Familial amyloidotic polyneuropathy (FAP) is an autosomally dominant inherited disorder associated with systemic amyloid deposition. FAP is distributed throughout the world and classified into four types based on clinical manifestations (Eanes and Glenner, 1968; Glenner et al., 1978). Type I FAP is the most common one characterized by a sensorimotor polyneuropathy affecting the lower extremities earlier and more severely than the upper. Autonomic dysfunction includes orthostatic hypotension, sexual impotence, urinary retention, and disturbance of gastrointestinal motility. More than two hundred FAP patients have been diagnosed in the northern part of Sweden.
KeywordsOrthostatic Hypotension RFLP Marker Swedish Patient Familial Amyloidotic Polyneuropathy Symptomless Carrier
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