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Familial Amyloidotic Polyneuropathy in Sweden — RFLP Analysis in Patients and in Healthy Controls

  • Gösta Holmgren
  • Anita Lindström
  • Ingrid Nordenson
  • Ola Sandgren
  • Lars Steen
  • Birgitta Svensson
  • Erik Lundgren
Chapter

Abstract

Familial amyloidotic polyneuropathy (FAP) is an autosomally dominant inherited disorder associated with systemic amyloid deposition. FAP is distributed throughout the world and classified into four types based on clinical manifestations (Eanes and Glenner, 1968; Glenner et al., 1978). Type I FAP is the most common one characterized by a sensorimotor polyneuropathy affecting the lower extremities earlier and more severely than the upper. Autonomic dysfunction includes orthostatic hypotension, sexual impotence, urinary retention, and disturbance of gastrointestinal motility. More than two hundred FAP patients have been diagnosed in the northern part of Sweden.

Keywords

Orthostatic Hypotension RFLP Marker Swedish Patient Familial Amyloidotic Polyneuropathy Symptomless Carrier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Gösta Holmgren
    • 1
  • Anita Lindström
    • 2
  • Ingrid Nordenson
    • 1
  • Ola Sandgren
    • 3
  • Lars Steen
    • 4
  • Birgitta Svensson
    • 1
  • Erik Lundgren
    • 2
  1. 1.Departments of Clinical GeneticsUniversity HospitalUmeåSweden
  2. 2.The Unit for Applied Molecular BiologyUniversity HospitalUmeåSweden
  3. 3.Ophthalmology, Internal MedicineUniversity HospitalUmeåSweden
  4. 4.Internal MedicineUniversity HospitalUmeåSweden

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