Studies on Transthyretin Metabolism in the Nervous System

  • Maria Joao Mascarenhas Saraiva
  • Adina Makover
  • Hisataka Moriwaki
  • William Blaner
  • Pedro P. Costa
  • DeWitt S. Goodman


Several points of evidence suggest that transthyretin (TTR) might play a significant role in the nervous system. First, TTR has been known to be present in CSF in disproportionately high concentrations, considering the molecular weight and hydrodynamic radius of TTR (1,2). The choroid plexuses of human and rat brain have been shown to be actively involved in the de novo synthesis of TTR. Initially this was first suggested by immunocheraical studies that showed TTR localized in choroid plexus epithelium (3,4). Very recently, the local synthesis of TTR in brain has been demonstrated through the use of specific cDNA probes for TTR mRNA; thus, TTR mRNA was detected in brain (5) and specifically in the choroid plexus epithelium (6,7).


Sciatic Nerve Serial Blood Sample Tissue Site Intravascular Injection Cyanuric Chloride 


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Maria Joao Mascarenhas Saraiva
    • 1
    • 2
  • Adina Makover
    • 1
  • Hisataka Moriwaki
    • 1
  • William Blaner
    • 1
  • Pedro P. Costa
    • 2
  • DeWitt S. Goodman
    • 1
  1. 1.Dept. of MedicineColumbia UniversityNew YorkUSA
  2. 2.Centro de Estudos de ParamiloidosePortoPortugal

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