Diverse Gene Structure for Serum Amyloid a Protein in Wild Mice
Serum amyloid A ( SAA ) gene family comprises four members which are closely linked in the 79 kb region of mouse chromosome. Two of these genes determine major mouse SAA isotypes, SAA1 and SAA2. Some mouse strains derived from wild mice show 2-fold intense SAA1/SAA2 mRNA induction as compared with BALB/c mice during acute phase reaction. Southern blot analysis of chromosamal DNA from these wild mice reveals duplication of the SAA1 and SAA2 genes, indicating that increased expression of the SAA1 and SAA2 genes in these mice is due to gene duplication. Since defective SAA gene expression cause resistence to amyloidosis, enhanced SAA gene expression may cause higher susceptibility of these mice to amyloisosis.
KeywordsGene Duplication Southern Blot Analysis Mouse Chromosome Acute Phase Reaction Wild Mouse
Unable to display preview. Download preview PDF.
- 3.Rosenthal, C.J., Franklin, E.C, Frangione, B. and Greenspan, J. J. Immunol. 116, 1415 (1976)Google Scholar
- 4.Anders, R.F., Natvig, J.B., Sletten, K., Husby, G. and Nordstoga, K. J. Immunol. 118, 229 (1977)Google Scholar
- 9.Lowell, CA., Potter, D.A., Stearman, R.S. and Morrow, J.F. Biol. J. Chem. 261, 8442 (1986)Google Scholar
- 10.Yamamoto, K., Goto, N., Kosaka, J., Shiroo, M., Dal Yeul, Y, and Migita, S. J. Immunol. 139, in press (1987)Google Scholar
- 11.Hoffman, J.S. and Benditt, E.P. J. Biol. Chem. 257, 10510 (1982)Google Scholar
- 16.Aviv, H. and Leder, P. Proc. Natl. Acad. Sci. USA 77, 5201 (1972)Google Scholar