Rat Liver and Lung Express Serum Amyloid A Related mRNAs
A vast number of systemic and metabolic changes occur in response to injury or infection. Among these events (the acute phase response) is the rise in concentration of a large number of plasma proteins of hepatic origin termed the acute phase proteins.1 Serum amyloid A is a family of acute phase proteins2,3 of unknown function and are apolipoproteins of HDL.4,5 In reactive amyloidosis amyloid A protein (AA) is the major protein constituent of the amyloid fibrils and amino terminal fragment of the plasma serum amyloid A protein.6,7,8 Not all SAA proteins are amyloidogenic though, since in the mouse there are three transcibed SAA genes (SAA1, SAA2, and SAA3) but only SAA2 is the precursor to murine AA protein.11
KeywordsSerum Amyloid cRNA Probe Amino Terminal Fragment Turpentine Injection Region Span Amino Acid
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