Serum Amyloid A: Characterization of Three cDNAS in One Individual and Complete Structure of their Corresponding Protein Products

  • Barbara Kluve-Beckerman
  • Francis E. Dwulet
  • Merrill D. Benson


Serum amyloid A (SAA) is an acute phase plasma protein. In addition, the 104-amino acid SAA molecule is the precursor to the 76-amino acid amyloid A protein (AA), the chief constituent of reactive amyloid deposits. Heterogeneity with respect to amino acid composition, sequence, and Chromatographie behavior has been reported for SAA and AA. The apparent polymorphic primary structure of SAA has lead to the hypothesis that particular SAA gene structures may be related to the development of amyloidosis. One approach to testing this hypothesis would be to look for SAA sequences common to reactive amyloid patients. Such a study would be facilitated by knowing the total number of genes a human has for SAA.


Southern Analysis Serum Amyloid Amino Acid Difference Sepharose CL6B Cesium Chloride 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Barbara Kluve-Beckerman
    • 1
  • Francis E. Dwulet
    • 1
  • Merrill D. Benson
    • 1
  1. 1.Departments of Medicine and Medical GeneticsIndiana University School of Medicine and VAMCIndianapolisUSA

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