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Monoclonal Antibody Against Synthesized Short Peptides Corresponding to Human Amyloid a Protein

  • Tadaaki Yokota
  • Tokuhiro Ishihara
  • Mutsuo Takahashi
  • Yoshimi Yamashita
  • Hiroo Kawano
  • Shunji Kawamura
  • Yoshihiro Fujinaga
  • Fumiya Uchino
  • Nobuo Hanai
  • Hajime Yoshida
  • Shinkichi Honda
  • Moriyuki Sato
Chapter

Abstract

Monoclonal antibody (McAb) was raised against synthesized short peptides corresponding to 37–47 residues from N-terminus of amino acid sequence of human AA protein. The McAb reacted immunohistochemically to amyloid tissues from cow, mouse, swan, and human AA amyloidosis. We concluded that the McAb was useful for identification of AA type amyloidosis of various species, and that the 37–47 residues were effective antigenic sites in AA protein.

Keywords

Amyloid Deposit Amyloid Fibril Short Peptide Amyloid Protein Familial Amyloid Polyneuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Tadaaki Yokota
    • 1
  • Tokuhiro Ishihara
    • 1
  • Mutsuo Takahashi
    • 1
  • Yoshimi Yamashita
    • 1
  • Hiroo Kawano
    • 1
  • Shunji Kawamura
    • 1
  • Yoshihiro Fujinaga
    • 1
  • Fumiya Uchino
    • 1
  • Nobuo Hanai
    • 1
    • 2
  • Hajime Yoshida
    • 1
    • 2
  • Shinkichi Honda
    • 1
    • 2
  • Moriyuki Sato
    • 1
    • 2
  1. 1.First Department of PathologyYamaguchi University School of MedicineUbe, Yamaguchi 755Japan
  2. 2.Tokyo Research LaboratoriesKyowa Hakko Kogyo Co., LTDMachida-shi, Tokyo 194Japan

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