Monoclonal Antibody Against Synthesized Short Peptides Corresponding to Human Amyloid a Protein
Monoclonal antibody (McAb) was raised against synthesized short peptides corresponding to 37–47 residues from N-terminus of amino acid sequence of human AA protein. The McAb reacted immunohistochemically to amyloid tissues from cow, mouse, swan, and human AA amyloidosis. We concluded that the McAb was useful for identification of AA type amyloidosis of various species, and that the 37–47 residues were effective antigenic sites in AA protein.
KeywordsAmyloid Deposit Amyloid Fibril Short Peptide Amyloid Protein Familial Amyloid Polyneuropathy
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