Experimental Systemic Amyloidosis in Mice-Induction of Amyloidosis by Immunization with Syngeneic Organ Extracts and Immunological Investigation
The exact pathogenesis of amyloidosis is not yet understood, and a number of attempts have been made to produce amyloidosis in animals. Casein was first substance found capable of inducing amyloidosis in animals, and subsequently several other animal models have been developed.2–4 in the induction of amyloidosis in these animal models, certain agents have been investigated as accelerating factors for development of amyloidosis,5–7 Or as blocking agents.8 More recently, reactions of cellular immunity involved T-,B-, and other immunological cells have been evaluated in the mechanism of amyloid deposition in animals.9,10 Transfer studies have also been reported using a model of experimental amyloidosis in animals.11 In these studies, exogeneous immunogens were used, and syngeneic tissue substances have not as yet been used. We have been able to produce systemic amyloidosis in mice by immunizing with syngeneic organ (liver or kidney) extracts and Freund’s complete adjuvant (FCA). This model will throw some light on the pathogenesis of amyloidosis.
KeywordsSpleen Cell Amyloid Deposition Recipient Mouse Liver Extract Systemic Amyloidosis
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