The Structure of Protein AA and its Correlation to the Tissue Distribution of Amyloid
Amino acid sequence has been determined in the two major protein AA subspecies 859-8.1 and 798-4.6 derived from two patients with different histological patterns of amyloid deposition. The subspecies 859-8.1 contained 50 residues, corresponding to SAA residues 1–50 with pI 8.1, while subspecies 798-4.6 contained at least 79 residues, corresponding to positions 2-80 of SAA with pI 4.6. Both of these AA proteins were purified from patients with patterns of amyloid deposition different from the common one in which protein AA contains a subspecies with 76 residues. It is concluded that there is a correlation between the size of protein AA and the distribution of amyloid, but the reason for this correlation remains unknown.
KeywordsAmyloid Deposition Amyloid Fibril Amino Acid Sequence Analysis Cyanogen Bromide Complete Amino Acid Sequence
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