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Use of Various Electroimmune Techniques in the Diagnosis and Follow-Up of Patients with AL Amyloidosis

  • Vittorio Bellotti
  • Eleonora Bucciarelli
  • Vittorio Perfetti
  • Giampaolo Merlini
  • Edoardo Ascari
Chapter

Summary

Bence Jones proteins isolated in 14 patients affected by AL amyloidosis were analyzed by SDS-PAGE and isoelectrofocusing followed by immunoblotting. In these patients we confirmed previous indications suggesting that amyloidogenic light chains are constituted by complete and incomplete molecules and, at least in patients with pattern I, they are strongly negatively charged.

Keywords

Light Chain Amyloid Fibril Molecular Weight Determination Plasma Cell Dyscrasia Bence Jones Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Vittorio Bellotti
    • 1
  • Eleonora Bucciarelli
    • 1
  • Vittorio Perfetti
    • 1
  • Giampaolo Merlini
    • 1
  • Edoardo Ascari
    • 1
  1. 1.Department of Internal Medicine, Institute of Clinical Medicine IIUniversity of PaviaItaly

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