Use of Various Electroimmune Techniques in the Diagnosis and Follow-Up of Patients with AL Amyloidosis
Bence Jones proteins isolated in 14 patients affected by AL amyloidosis were analyzed by SDS-PAGE and isoelectrofocusing followed by immunoblotting. In these patients we confirmed previous indications suggesting that amyloidogenic light chains are constituted by complete and incomplete molecules and, at least in patients with pattern I, they are strongly negatively charged.
KeywordsLight Chain Amyloid Fibril Molecular Weight Determination Plasma Cell Dyscrasia Bence Jones Protein
Unable to display preview. Download preview PDF.
- 3.G. Merlini, M. Mastanduno, P. Moy, and E.F. Osserman, Immunoglobulin light chain fragments in the serum and urine of patients with AL amyloidosis. Clin.Res. 33:559 A (1986)Google Scholar
- 9.A.D. Snow, J. Willmer, and R. Kisilevsky, Sulfated glycosamino-glycans: a common constituent of all amyloids? Lab.Invest. 56:120 (1987)Google Scholar