Structural Analysis of a Lambda IV Primary Amyloid Protein
Immunoglobulin type systemic amyloidosis is the result of the deposition of monoclonal immunoglobulin light chain proteins which have aggregated into fibrils having a beta pleated sheet configuration. These fibril deposits cause disease by displacement of tissue structures with resultant interference with normal body functions. The highly organized beta structure of the fibrils accounts for resistance to proteolytic cleavage and therefore the progressive nature of the process.
KeywordsTryptic Peptide Amyloid Fibril Fibril Formation Amyloid Protein Iodoacetic Acid
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