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Structural Analysis of a Lambda IV Primary Amyloid Protein

  • Merrill D. Benson
  • Francis E. Dwulet
  • Deborah Madura
  • Gary Wheeler
Chapter

Abstract

Immunoglobulin type systemic amyloidosis is the result of the deposition of monoclonal immunoglobulin light chain proteins which have aggregated into fibrils having a beta pleated sheet configuration. These fibril deposits cause disease by displacement of tissue structures with resultant interference with normal body functions. The highly organized beta structure of the fibrils accounts for resistance to proteolytic cleavage and therefore the progressive nature of the process.

Keywords

Tryptic Peptide Amyloid Fibril Fibril Formation Amyloid Protein Iodoacetic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Merrill D. Benson
    • 1
  • Francis E. Dwulet
    • 1
  • Deborah Madura
    • 1
  • Gary Wheeler
    • 1
  1. 1.Departments of Medicine and Medical GeneticsIndiana University School of Medicine, VAMCIndianapolisUSA

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