The Amino Acid Sequence of a Carbohydrate-Containing Immuno-Globulin-Light-Chain-Type Amyloid Fibril Protein (AL)

  • Ole Kristoffer Olstad
  • Knut Sletten
  • Kim Toft
  • Per Westermark


The amino acid sequence of AL chain So124 was established from N-terminal analyses of the protein itself and on peptides derived after tryptic digestion, digestion with protease V8, digestion with thermolysin and cleavage with BNPS-skatole. The protein was found to consist of 103 amino acid residues and had an oligosaccharide chain linked to an asparagine residue in position 72. The AL chain was most homologous to the variable region of k-type subgroup III.


Amyloid Fibril Tryptic Digestion Complete Amino Acid Sequence Immunoglobulin Light Chain High Performance Liquid Chromato 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Ole Kristoffer Olstad
    • 1
    • 2
  • Knut Sletten
    • 1
    • 2
  • Kim Toft
    • 1
    • 2
  • Per Westermark
    • 1
    • 2
  1. 1.Department of BiochemistryUniversity of OsloOsloNorway
  2. 2.Institute of PathologyUniversity of UppsalaUppsalaSweden

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