Enhanced Degradation of Serum Amyloid Protein SAA in vivo by Proteolytic Enzymes
Despite a considerable accumulation of new knowledge about amyloid proteins, the treatment of amyloidosis is very difficult and usually ineffective (1,2) for this reason many different approaches have been tried, including prevention of amyloid precursor synthesis, renovai or dissolution of amyloid fibrils and prevention of deposition of amyloid fibrils (Table 1). Discussions of these approaches have recently been published (3,4). We here report sane experiments in which proteolytic enzymes were used to enhance the degradation of amyloid precursor proteins, such as SAA. This can be achieved in vitro by the addition of proteolytic enzyme activators e.g. strepto-or urokinase to serum (5).
KeywordsClearance Rate Amyloid Fibril Aspergillus Oryzae Amyloid Protein Plasma Cell Dyscrasia
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