Experimental Amyloidosis of Rabbit Induced by Saponin

  • Kenji Sano
  • Masayuki Fujiwara
  • Masao Hotchi
  • Tomotaka Shinoda


It is well known that experimental amyloidosis is induced by injection of various materials, such as casein, Escherichia coli endotoxin, Candida albicans and so on1. Saponin, a glycoside mixture of the white soaproot of Gypsophilia species, was also found out to be one of the amyloidogenic agents2.The present paper describes the light and electron microscopic appearances of amyloidosis in the kidney and other organs induced by saponin. The experiment was also undertaken to clarify the initial change in the kidney by sequential biopsies. Furthermore, major protein constituent of the amyloid substance in these animals was purified and its amino acid composition and residue sequence were analyzed.


Amyloid Deposit Amyloid Fibril Amyloid Protein Renal Amyloidosis Residue Sequence 


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Kenji Sano
    • 1
  • Masayuki Fujiwara
    • 1
  • Masao Hotchi
    • 1
  • Tomotaka Shinoda
    • 2
  1. 1.Department of PathologyShinshu University School of MedicineMatsumotoJapan
  2. 2.Department of ChemistryTokyo Metropolitan UniversityTokyoJapan

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