Treatment of Autonomic Disorders of Familial Amyloid Polyneuropathy with L-Threo-3,4-Dihydroxyphenyserine
Familial amyloid polyneuropathy (FAP) is a hereditary systemic amyloidosis characterized by polyneuropathy and severe autonomic disorders1. Autonomic disorders of FAP include orthostatic hypotension, gastrointestinal symptoms, urinary disturbance and impotence. Among them, orthostatic hypotension restricts activities of patients, but there has been no beneficial treatment. Recent reports showed6,7 that the intravenous or oral administration either of L-or DL-threo-3,4-dihydroxyphenylserine (L-,DL-DOPS) had a short term effect on orthostatic hypotension of FAP. In this paper we evaluated the effet of the oral administration of L-DOPS on the orthostatic hypotension and the gastrointestinal symptoms in FAP.
KeywordsGastrointestinal Symptom Orthostatic Hypotension Nagano Prefecture Familial Amyloid Polyneuropathy Clin Neurol
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