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Treatment of Autonomic Dysfunction with L-Threo-3,4-Dihydroxyphenylserine in Patients with Familial Amyloidotic Polyneuropathy: A Multicenter Study

  • Tomokazu Suzuki
  • Tsutomu Azuma
  • Shukuro Araki
  • Shinichi Ikegawa
  • Shozo Kito
  • Hiroaki Matsubayashi
  • Nobuo Yanagisawa
  • Shu-ichi Ikeda
Chapter

Abstract

Type 1 familial amyloidotic polyneuropathy(FAP) is a late onset inherited disorder characterized by polyneuropathy and autonomic failure. Autonomic visceral neuropathies affect every organ system and present as extensive and severe autonomic manifestations. Conventional therapies barely relieve afflicted patients. L-threo-3,4-dihydroxyphenylserine(L-threo-DOPS), an immediate precursor of (−)-norepinephrine, has recently been adopted as a promising drug, based on findings that suggest norepinephrine depletion from sympathetic nerve endings and denervation supersensitivity in the disorder1. The beneficial effects of racemic DL-threo-DOPS on orthostatic hypotension in FAP were also reported at preceding Symposia2,3.

Keywords

Orthostatic Hypotension Familial Amyloid Polyneuropathy Familial Amylaidatic Polyneuropathy Sympathetic Nerve Ending Elevated Systolic Blood Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Tomokazu Suzuki
    • 1
  • Tsutomu Azuma
    • 1
  • Shukuro Araki
    • 1
    • 2
  • Shinichi Ikegawa
    • 1
    • 2
  • Shozo Kito
    • 1
    • 3
  • Hiroaki Matsubayashi
    • 1
    • 3
  • Nobuo Yanagisawa
    • 1
    • 4
  • Shu-ichi Ikeda
    • 1
    • 4
  1. 1.Dept. of Int. Med.Osaka Univ. Hosp.OsakaJapan
  2. 2.Dept. of Int. Med.Kumamoto Univ. Med. SchoolJapan
  3. 3.Dept. of Int. Med.Hiroshima Univ. School of Med.Japan
  4. 4.Dept. of Med.Shinshu Univ. School of Med.Japan

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