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Evaluation of Serum Variant Prealbumin Levels, and its Behavior after Plasma Exchange for Familial Amyloidotic Polyneuropathy (Type 1)

  • Shinichi Ikegawa
  • Sumio Tanase
  • Yoshimasa Morino
  • Shigehiro Yi
  • Yukio Ando
  • Akira Miyazaki
  • Shukuro Araki
Chapter

Abstract

Type 1 familial amyloidotic polyneuropathy (FAP) is an autosomal dominant systemic amyloidosis, characterized by extracellular amyloid deposition and sensory dominant polyneuropathy accompanied by autonomic dysfunction.1 2. Biochemical research disclosed that the amyloid fibril protein in type 1 FAP consists of a variant prealbumin (PA) (transthyretin), due to a single amino acid substitution, a methionine for valine at position 30.3 5 Recently, FAP and its carrier state were identified by the detection of the variant PA in serum.6 9

Keywords

Plasma Exchange Homoserine Lactone Familial Amyloidotic Polyneuropathy Cellulose Bead Asymptomatic Family Member 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Shinichi Ikegawa
    • 1
  • Sumio Tanase
    • 2
  • Yoshimasa Morino
    • 2
  • Shigehiro Yi
    • 1
  • Yukio Ando
    • 1
  • Akira Miyazaki
    • 1
  • Shukuro Araki
    • 1
  1. 1.The First Department of Internal MedicineKumamoto University Medical SchoolKumamoto 860Japan
  2. 2.Department of BiochemistryKumamoto University Medical SchoolKumamoto 860Japan

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