DMSO Therapy Using Dermal Application to Patients with Systemic Amyloidosis

  • Takashi Isobe
  • Junji Matsumoto
  • Shin-ichi Shimizu
  • Takuo Fujita
  • Takeshi Kashiwabara


Polymerized amyloid fibrils can be dissociated by dimethylsulfoxide (DMSO) in vitro and in vivo (Isobe and Osserman, 1976; Wegelius, 1982). It is also suggested that antiinflammatory action of DMSO induces the fall of SAA levels indicating the possibility of a decrease in amyloed formation in AA amyloidosis (van Rijswisk, 1979). Because of frequent complaints of peculiar smell by oral intake of DMSO among patients, dermal (cutaneous) application has been examined in this study. Continous dermal DMSO treatment (3–10 g/day) was given to patients with systemic amyloidosis. In the 2 patients with secondary amyloidosis and in one patient with AL type, obvious clinical responses were observed in the present study.


Carpal Tunnel Syndrome Systemic Amyloidosis Monoclonal Immunoglobulin Secondary Amyloidosis Bence Jones Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bonnetblanc, J.M., Catanzano, G., and Roux, J., 1980, Acta Derm (Stockholm), 60:91.Google Scholar
  2. 2.
    Eisenbud, L.E., Lerner, C.P., and Chai, C.K., 1981, The effect of dimethyl suifoxide (DMSO) upon spontaneous amyloidosis in mice, Proc Soc Exp Biol Med, 168:172.Google Scholar
  3. 3.
    Giacchino, F., Stratta, P. et al, 1980, Renal amyloidosis and treatment with dimethylsulfoxide (DMSO), Min Nefr, 27:599.Google Scholar
  4. 4.
    Hanai, N., Ishihara, T. et al., 1979, Effects of dimethyl sulfoxide and colchicine on the resorption of experimental amyloid, Virchow Archiv A, 384:45.Google Scholar
  5. 5.
    Isobe, T., and Osserman, E.F., 1976, Effect of dimethyl sulfoxide (DMSO) in Bence Jones proteins, amyloid fibrils and casein-induced amyloirosis, in: Amyloidosis, O. Wegelius and A. Pasternack, ed., Academic Press, New York.Google Scholar
  6. 6.
    Isobe, T., Matsumoto, J., Tomita, M., 1980, Differential diagnosis of 105 Japanese patients with systemic amyloidosis, Jap J Med, 55:105.Google Scholar
  7. 7.
    Kedar, I., Greenwald, M., Ravid, M., 1977, Treatment of experimental murine amyloidosis with dimethyl sulfoxide, Eur J Clin Invest, 7:149.CrossRefGoogle Scholar
  8. 8.
    Kisilevsky, R., Boudreau, L., and Foster, D., 1983, Kinetics of amyloid deposition. II. The effects of dimethylsulfoxide and colchicine therapy, Lab Invest, 48:60.Google Scholar
  9. 9.
    Kito, S., Itoga, E., et al., 1983, Studies on biological actions of dimethyl sulfoxide in familial amyloidosis. NY Acad Sci, 52.Google Scholar
  10. 10.
    Kodama, F., Motomura, S., Itoh, A. et al., 1981, Trials of intravenous dimethyl sulfoxide therapy and scanning for soft-tissue amyloid to a patient with amyloidosis associated with multiple myeloma: a case report, Acta Hemat Jap, 44:887.Google Scholar
  11. 11.
    Osserman, E.F., Sherman, W.H., and Kyle, A., 1980, Further studies of therapy of amyloidosis with dimethyl sulfoxide (DMSO), in: Amyloid and amyloidosis, G.G. Glenner, P.P. Costa, F. Freitas, ed., Excerpta Medica, Amsterdam.Google Scholar
  12. 12.
    Ravid, M., Shapira, J., Lang, R., and Kedar, I., 1982, Prolonged dimethylsulfoxide treatment in 13 patients with systemic amyloidosis. Ann Rheum Dis, 41:587.CrossRefGoogle Scholar
  13. 13.
    Tribe, C.R., Poulding, J.M., Harrison, P., and Bacon, P.A., 1983, A quantitative method for assessing amyloid in renal biopsies, in: Amyloidosis E.A.R.S., C.R. Tribe and P.A. Bacon, ed., John Wright & Sons, Bristol.Google Scholar
  14. 14.
    van Rijswijk, M.H., Ruinen, L., Donker, A. et al., 1980, Successful treatment with dimethyl sulfoxide of human amyloidosis secondary to rheumatoid arthritis, in: Amyloid and amyloidosis, G.G. Glenner, P.P. Costa, F. Freitas, ed., Excerpta Medica, Amsterdam.Google Scholar
  15. 15.
    van Rijswijk, M.H., van Leeuwen, M.A., Donker, A., and Mandema, E., 1986, Treatment of systemic AA amyloidosis. in: Amyloidosis, G.G. Glenner, E.F. Osserman, et al. ed., Plenum Publishing Co, New York.Google Scholar
  16. 16.
    Wegelius, O., 1982, The resolution of amyloid substance, Acta Med Scand, 212:273.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Takashi Isobe
    • 1
  • Junji Matsumoto
    • 1
  • Shin-ichi Shimizu
    • 1
  • Takuo Fujita
    • 1
  • Takeshi Kashiwabara
    • 1
  1. 1.Department of MedicineKobe UniversityKobeJapan

Personalised recommendations