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Histologic Characterization of Amyloidosis Based on Amyloid Proteins

  • Takako Iwata
  • Tadaaki Yokota
  • Tokuhiro Ishihara
  • Mutsuo Takahashi
  • Yoshimi Yamashita
  • Takaaki Nagasawa
  • Toshikazu Gondo
  • Hiroo Kawano
  • Toshiaki Kamei
  • Yoshiko Okuzono
  • Fumiya Uchino
Chapter

Abstract

Using the immunohistochemical technique, variable types of amyloid fibril protein can be easily identified on formalin-fixed and paraffin-embedded tissue sections. In this study, histopathologic features of systemic amyloidosis in 104 autopsy cases were reviewed and investigated whether there was a relationship between the chemical types of amyloid proteins and the tissue distribution of amyloid deposits. Morphologically, the most characteristic feature was that all cases of AA amyloidosis examined showed “vascular amyloidosis” and the small arteries of many organs were mainly affected by amyloid. Although diffuse deposition of amyloid in AA type was found in the thyroid gland and mucosal layers of the alimentary tracts, no amyloid deposition was found in the parenchyma of the liver, spleen and/or adrenal. In the kidney, nodular deposition of amyloid was found in the glomeruli.

On the other hand, 44% of AL cases were “parenchymal amyloidosis” and the space of Disse or the red pulp of the spleen were diffusely occupied by amyloid deposits. In the alimentary tracts, a characteristic finding was diffuse deposition of amyloid in the muscular layers. In the glomeruli, linear amyloid deposits were found along the basement membrane. The vascular amyloidosis was also found in AL.

From the present study, it is concluded that there are some significant differences in the manner of amyloid deposition between AA and AL amyloidosis.

Keywords

Amyloid Deposit Alimentary Tract Amyloid Protein Systemic Amyloidosis Portal Triad 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P. Westermark, K. H. Johnson, and P. Pitkaenen: Systemic amyloidosis: a review with emphasis on pathogenesis. Appl. Pathol., 3:55 (1985).Google Scholar
  2. 2.
    G. Husby and K. Sletten: Chemical and clinical classification of amyloidosis 1985. Scand. J. Immunol., 23:253 (1986).CrossRefGoogle Scholar
  3. 3.
    A. S. Cohen and I. H. Connors: The pathogenesis and biochemistry of amyloidosis. J. Pathol., 151:1 (1987).CrossRefGoogle Scholar
  4. 4.
    S. Fujihara: Differentiation of amyloid fibril proteins in tissue sections. Two simple and reliable histological methods applied to fifty-one cases of systemic amyloidosis. Acta Pathol. Jpn., 32:771 (1982).Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Takako Iwata
    • 1
  • Tadaaki Yokota
    • 1
    • 2
  • Tokuhiro Ishihara
    • 1
    • 2
  • Mutsuo Takahashi
    • 1
    • 2
  • Yoshimi Yamashita
    • 1
    • 2
  • Takaaki Nagasawa
    • 1
    • 2
  • Toshikazu Gondo
    • 1
    • 2
  • Hiroo Kawano
    • 1
    • 2
  • Toshiaki Kamei
    • 1
    • 2
  • Yoshiko Okuzono
    • 1
    • 2
  • Fumiya Uchino
    • 1
    • 2
  1. 1.The School of Allied Health SciencesYamaguchi University, UbeYamaguchi 755Japan
  2. 2.First Department of PathologyYamaguchi University School of Medicine UbeYamaguchi 755Japan

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