An Autopsied Case of Systemic Light Chain Deposition Disease (LCDD): The Relationship between LCDD and AL Amyloidosis

  • Mitsuyasu Toyoda
  • Akira Kajita
  • Sumie Manno
  • Kei Furiya
  • Shigeo Kita
  • Tomotaka Shinoda
Chapter

Abstract

A case of the systemic light chain deposition disease in a 48-year-man is presented. The patient showed antemortem the signs of multiple organ failure, but without that of myeloma. Autopsy revealed generalized of hyaline-eosinophilic, Congo red negative substance. It was ultra-structurally differed from amyloid fibril. In bone marrow, myelomatous proliferations of plasma cells positive for kappa light chain were abundant. Deposited substance was identified as kappa light chain by immuno-histochemical and immunoelectron method. Biochemical and immunohistochemical findings on LCDD proteins extracted from the liver tissues, suggested that degradation process and amino acid composition and antigenecity of LCDD protein resembled to those of the AL proteins in AL amyloidosis.

Keywords

Tyrosine Anemia Lysine Arginine Methionine 

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Mitsuyasu Toyoda
    • 1
    • 2
  • Akira Kajita
    • 1
    • 2
  • Sumie Manno
    • 1
    • 2
  • Kei Furiya
    • 1
    • 2
  • Shigeo Kita
    • 1
    • 2
  • Tomotaka Shinoda
    • 1
    • 2
  1. 1.Department of Pathology, Department of Biochemistry Division of electron micro scopy laboratoryTokyo Women’s Medical CollegeJapan
  2. 2.Department of ChemistryTokyo Metropolitan UniversitySetagaya-ku Tokyo 158Japan

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