Advertisement

Amyloidosis Associated with Systemic Lupus Erythematosus

  • Shigeo Nomura
  • Tadashi Kanoh
Chapter

Abstract

Secondary amyloidosis is known to occur frequently in patients with rheumatoid arthritis. However, only several cases of amyloidosis associated with systemic lupus erythematosus (SLE) have been reported previously in the literature. In this report, we describe two patients with amyloidosis associated with SLE. The first patient had pulmonary amyloidosis, and the second patient had systemic amyloidosis involving the lungs, heart, liver, spleen, kidneys, intestines, bone marrow and skin. The varying duration of SLE before the development of amyloidosis might be correlated to the balance of the amount of production of SAA and its enzymatic cleavage. We diagnosed these two cases in a period of less than two years. These cases reflect a high incidence of amyloidosis as the result of longer survival of patients with SLE due to treatment with steroid hormones. Physicians should be alert to the risk of amyloidosis in SLE patients on steroid therapy.

Keywords

Systemic Lupus Erythematosus Nephrotic Syndrome Systemic Lupus Erythematosus Patient Force Vital Capacity Systemic Amyloidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    O. Wegelius, Amyloidosis of the kidneys, adrenals and spleen as a complication of acute disseminated lupus erythematosus treated with ACTH and cortisone, Acta Med Scand. 156: 91 (1956).CrossRefGoogle Scholar
  2. 2.
    L. A. Schleissner, W. W. Sheehan, and R. C. Orselli, Lupus erythematosus in a patient with amyloidosis, adrenal insufficiency, and subsequent immunoblastic sarcoma: demonstration of the LE phenomenon in the lung, Arthritis Rheum. 19: 249 (1976).CrossRefGoogle Scholar
  3. 3.
    R. W. King, Jr, and W. F. Falls, Jr, Renal amyloidosis: development in a case of systemic lupus erythematosus, Clin Nephrol. 6: 497 (1976).Google Scholar
  4. 4.
    H. Maldykowa, and B. Dratwianka, Amyloidosis in the course of systemic lupus erythematosus, Rhumatologie. 6: 609 (1976).Google Scholar
  5. 5.
    S. Webb, F. Segura, F. Cervantes, A. Darnell, E. Soriano, M. Ribas-Mundo, and J. G. Miguel, Systemic lupus erythematosus and amyloidosis, Arthritis Rheum. 22: 554 (1979).CrossRefGoogle Scholar
  6. 6.
    P. H. B. Carstens, L. L. Ogden, Jr, and W. P. Peak, Renal amyloidosis associated with systemic lupus erythematosus, Am J Clin Pathol. 74: 835 (1980).Google Scholar
  7. 7.
    D. P. Huston, K. P. W. J. McAdam, J. E. Balow, R. Bass, and R. A. DeLellis, Amyloidosis in systemic lupus erythematosus, Am J Med. 70: 320 (1981).CrossRefGoogle Scholar
  8. 8.
    J. Sweet, R. A. Bear, and A. P. Lang, Amyloidosis and systemic lupus erythematosus, Hum Pathol. 12: 853 (1981).CrossRefGoogle Scholar
  9. 9.
    M. G. Ridley, P. J. Maddison, and C. R. Tribe, Amyloidosis and systemic lupus erythematosus, Ann Rheum Dis. 43: 649 (1984).CrossRefGoogle Scholar
  10. 10.
    S. Nomura, N. Kumagai, T. Kanoh, H. Uchino, and J. Kurihara, Pulmonary amyloidosis associated with systemic lupus erythematosus, Arthritis Rheum. 29: 680 (1986).CrossRefGoogle Scholar
  11. 11.
    F. C. de Beer, R. K. Mallya, E. A. Fagan, J. G. Lanham, G. R. V. Hughes, and M. B. Pepys, Serum amyloid-A protein concentration in inflammatory diseases and its relationship to the incidence of reactive systemic amyloidosis, Lancet. 2: 231 (1982).CrossRefGoogle Scholar
  12. 12.
    G. G. Glenner, Amyloid deposits and amyloidosis — the β-fibrilloses I, N Engl J Med. 302: 1283 (1980).CrossRefGoogle Scholar
  13. 13.
    G. G. Glenner, Amyloid deposits and amyloidosis — the β-fibrilloses II, N Engl J Med. 302: 1333 (1980).CrossRefGoogle Scholar
  14. 14.
    G. G. Glenner, P. Pinho e Costa, and F. deFreitas, “Amyloid and amyloidosis,” Excerpta Medica, Amsterdam (1980).Google Scholar
  15. 15.
    M. D. Benson, and A. S. Cohen, Serum amyloid A protein in amyloidosis, rheumatic and neoplastic diseases, Arthritis Rheum. 22: 36 (1979).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Shigeo Nomura
    • 1
  • Tadashi Kanoh
    • 1
    • 2
  1. 1.Department of Internal MedicineHyogo Prefectural Amagasaki HospitalHyogoJapan
  2. 2.The First Division, Department of Internal Medicine, Faculty of MedicineKyoto UniversityKyotoJapan

Personalised recommendations