Amyloidosis Associated with Systemic Lupus Erythematosus

  • Shigeo Nomura
  • Tadashi Kanoh


Secondary amyloidosis is known to occur frequently in patients with rheumatoid arthritis. However, only several cases of amyloidosis associated with systemic lupus erythematosus (SLE) have been reported previously in the literature. In this report, we describe two patients with amyloidosis associated with SLE. The first patient had pulmonary amyloidosis, and the second patient had systemic amyloidosis involving the lungs, heart, liver, spleen, kidneys, intestines, bone marrow and skin. The varying duration of SLE before the development of amyloidosis might be correlated to the balance of the amount of production of SAA and its enzymatic cleavage. We diagnosed these two cases in a period of less than two years. These cases reflect a high incidence of amyloidosis as the result of longer survival of patients with SLE due to treatment with steroid hormones. Physicians should be alert to the risk of amyloidosis in SLE patients on steroid therapy.


Systemic Lupus Erythematosus Nephrotic Syndrome Systemic Lupus Erythematosus Patient Force Vital Capacity Systemic Amyloidosis 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Shigeo Nomura
    • 1
  • Tadashi Kanoh
    • 1
    • 2
  1. 1.Department of Internal MedicineHyogo Prefectural Amagasaki HospitalHyogoJapan
  2. 2.The First Division, Department of Internal Medicine, Faculty of MedicineKyoto UniversityKyotoJapan

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