Immunohistochemical and Ultrastructural Studies of Amyloid Deposition in Squamous Cell Carcinoma of Uterine Cervix
Amyloid depositions were detected in five patients with squamous cell carcinoma of the uterine cervix. The deposits were located both among the tumor cells and in the stroma, and showed nodular and star-like appearance. The amyloid reacted only with polyclonal anti-keratin antiserum on fresh frozen sections, whereas it did not react with anti-AA, anti-Aλ, anti-Aκ, and anti-prealbumin antisera. These results suggest that the precursor protein of the amyloid may be keratin derived from the tumor cells. Based On ultrastructural study, it is indicated that nodular amyloid deposits originate from special degeneration (apoptosis) of the tumor cells, and that star-like amyloid deposits are formed within the cytoplasm or in the vicinity of invaginated cytoplasmic membranes of the tumor cells.
KeywordsPituitary Adenoma Basal Cell Carcinoma Nasopharyngeal Carcinoma Amyloid Deposit Amyloid Fibril
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