Amyloid Localized to Tenosynovium at Carpal Tunnel Release: The Natural History of 124 Cases
The carpal tunnel syndrome results from entrapment of the median nerve from a variety of systemic diseases including rheumatoid arthritis, myxedema, systemic lupus erythematosus, acromegaly, diabetes, and amyloidosis as well as dislocation or fracture of the carpal bones or osteophytes. The carpal tunnel syndrome is present in about one-fourth of patients at the time of diagnosis of primary systemic amyloidosis (AL) (Kyle and Greipp, 1983). The incidence of amyloid deposits in the flexor synovialis or the transverse carpal ligament of patients with carpal tunnel syndrome is low—7% in one report (Yamaguchi et al, 1965) and 1% in another (Bastian, 1974). The clinical significance of amyloid in the tenosynovium or carpal ligament in the absence of systemic amyloidosis is unknown. This prompted us to review our experience.
KeywordsMedian Nerve Carpal Tunnel Syndrome Abdominal Aortic Aneurysm Carpal Tunnel Amyloid Deposit
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