Amyloid in the Skin of Patients Undergoing Long-Term Hemodialysis

  • Mariko Taira
  • Masaru Ohashi
  • Akira Ito
  • Kazuo Masuko


Amyloidosis associated with long-term hemodialysis is related to β2 microglobulin (β2MG)1,2. The incidens is high in cases of long duration of hemodialysis. Amyloid deposits are observed in several organs: carpal tunnel3,4,5,6,7 joints, bone8, blood vessels of rectal biopsy specimens2,5 and skin5,6, and there seems to be sytemic involvement. Skin changes in hemodialysis Mitientt. include hyperpigmentation, purpura, xerosis and generalized pruritus9. We examined the hyperpigmented skin lesions of hemodialysis patients whether or not the amyloid related to β2 MG was a cause of these akuin chances.


Carpal Tunnel Amyloid Fibril Immunoelectron Microscopy Sweat Duct Dermal Vessel 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Mariko Taira
    • 1
  • Masaru Ohashi
    • 1
  • Akira Ito
    • 2
  • Kazuo Masuko
    • 2
  1. 1.Department of DermatologyNagoya University School of MedicineShowa-ku, Nagoya, 466Japan
  2. 2.Shusaikai Masuko hospitalNagoya, 453Japan

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