Amyloid in the Skin of Patients Undergoing Long-Term Hemodialysis

  • Mariko Taira
  • Masaru Ohashi
  • Akira Ito
  • Kazuo Masuko
Chapter

Abstract

Amyloidosis associated with long-term hemodialysis is related to β2 microglobulin (β2MG)1,2. The incidens is high in cases of long duration of hemodialysis. Amyloid deposits are observed in several organs: carpal tunnel3,4,5,6,7 joints, bone8, blood vessels of rectal biopsy specimens2,5 and skin5,6, and there seems to be sytemic involvement. Skin changes in hemodialysis Mitientt. include hyperpigmentation, purpura, xerosis and generalized pruritus9. We examined the hyperpigmented skin lesions of hemodialysis patients whether or not the amyloid related to β2 MG was a cause of these akuin chances.

Keywords

Paraffin Fibril Amyloidosis Purpura Verse 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    F. Gejyo, T. Yamada, S. Odani, Y. Nakagawa, M. Arakawa, T. Kunitomo, H. Kataoka, M. Suzuki, Y. Hirasawa, T. Shirahama, A.S. Cohen, and K. Schmid, A new form of amyloid protein associated with hemodialysis was identified as β2-microglobulin. Biochem Biophys Res Commun 129:701 (1985)CrossRefGoogle Scholar
  2. 2.
    T. Shirahama, M. Skinner, A.S. Cohen, F. Gejyo, M. Arakawa, M. Suzuki, and Y. Hirasawa, Histochemical and immunohistochemical characterization of amyloid associated with chronic hemodialysis as β2 micro-globulin. Lab Invest 53:705 (1985)Google Scholar
  3. 3.
    D.J. Warren, L.S. Otieno, Carpal tunnel syndrome in patients on intermittent haemodialysis. Postgrad Med J 51: 450 (1975)CrossRefGoogle Scholar
  4. 4.
    H. Assenat, E. Calemard, B. Charra, G. Laurent, J.C. Terrat, T. Vanel, Hémodialyse syndrome du canal carpien et substance amyloide, Nouv Presse Med 9: 1715 (1980)Google Scholar
  5. 5.
    H.G. Kachel, P. Altmeyer, C.A. Baldamus, K.-M. Koch, Deposition of an amyloid-like substance as a possible complication of regular dialysis treatment. Contri Nephrol 36: 127 (1983)Google Scholar
  6. 6.
    P. Altmeyer, H.G. Kachel und U. Runne, Mikroangiopathie, Bindegewebs-veranderungen und amyloidartige Ablagerungen bei chronischer Niereninsuffizienz. Der Hautarzt 34: 277 (1983)Google Scholar
  7. 7.
    A. Schwarz, F. Keller, S. Seyfert, W. Pöil, M. Molzahn and A. Distler, Carpal tunnel syndrome: a major complication in long-term hemodialysis patients, Clin Nephrol 22: 133 (1984)Google Scholar
  8. 8.
    J.M. Gómez, E.B. Barado, R.G. Perez, E.L. Buisán, E.S. Sobrevia, J.R. Querol, and M.S. Arqués, Amyloid arthropathy in patients undergoing periodical haemodialysis for chronic renal failure: a new complication, Ann Rheum Dis. 44: 729 (1985)CrossRefGoogle Scholar
  9. 9.
    B.A. Gelchrest, J.W. Rowe, Cutaneous aspects ofrenal disease in “Dermatology in general medicine” T.B. Fitzpatrick, ed 3. McGraw-Hill Book Co, New York, (1987)Google Scholar
  10. 10.
    L.H. Connors, T. Shirahama, M. Skinner, A. Fenves, and A.S. Cohen. In vitro formation of amyloid fibrils from intact β2-microglobulin. Biochem Biophys Res Commun 131: 1063 (1985)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Mariko Taira
    • 1
  • Masaru Ohashi
    • 1
  • Akira Ito
    • 2
  • Kazuo Masuko
    • 2
  1. 1.Department of DermatologyNagoya University School of MedicineShowa-ku, Nagoya, 466Japan
  2. 2.Shusaikai Masuko hospitalNagoya, 453Japan

Personalised recommendations