Immunohistochemical Staining Properties of Cutaneous Amyloidosis Using Anti-Keratin Monoclonal Antibodies
There are several groups of amyloidosis which occure in human skin. They are primary systemic amyoidosis(the amyloid protein of which is immuno-globulin light chains; AL), secondary systemic amyloidosis(the amyloid protein of which is amyloid A protein; AA), heredofamilial amyloid polyneuropathy; AF) and another one group is primary localized cutaneous amyloidosis. Recently, some authors1,2,3 have demonstrated that cryostat sections of primary localized cutaneous amyloidosis were positively stained with anti-keratin antibodies and they have hypothesized that the precursor protein of primary localized cutaneous amyloidosis might be keratin protein from epidermal cells. But there are another reports which have shown that anti-keratin antibodies did not react with amyloid deposits of primary localized cutaneous amyloidosis4,5.
KeywordsAmyloid Deposit Amyloid Protein Systemic Amyloidosis Normal Human Skin Outer Root Sheath
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