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ASSAM Amyloidosis is Present in Aging Mice of Many Strains, not Only in SAM

  • Toshio Takeda
  • Keiichi Higuchi
  • Masanori Hosokawa
Chapter

Abstract

Senescence accelerated mouse (SAM) is a murine model of accelerated senescence and consists of SAM-P (accelerated senescence-prone mice, P/l, P/2, P/3, P/4, P/6, and P/8 series) and SAM-R (accelerated senescence-resistant mice, R/l, R/2, and R/3 series), with the usual features of ageing.1•6 One of the most characteristic findings in SAM is the spontaneous age-associated systemic amyloidosis.6,7 The extensive deposition of senile amyloid fibril protein occurs extracellularly with advancing age in SAM-P/1 and SAM-P/2 but rarely in SAM-R, before they reach 20 months of age.7 A unique senile amyloid fibril protein termed “ASSAM” has been isolated from the liver of SAM-P/1.8 This protein differs from amyloid proteins from any other spontaneous or secondary murine amyloidosis, in biochemical and in immunochemical properties.8,9

Keywords

Amyloid Deposition Amyloid Fibril Amyloid Protein Acetone Powder Immunochemical Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Toshio Takeda
    • 1
  • Keiichi Higuchi
    • 1
  • Masanori Hosokawa
    • 1
  1. 1.Department of PathologyChest Disease Research Institute Kyoto University Sakyo-kuKyoto 606Japan

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