Abstract
In the aging heart a localized amyloid restricted to the atria frequently occurs. This amyloid is designated isolated atrial amyloid (IAA). In the atria a natriuretic hormone, known as atrial natriuretic peptide (ANP), is produced. In this study, we show that antisera to IAA and to ANP both stain atrial muscle cells and atrial amyloid. Furthermore, a small protein purified from IAA had an amino acid sequence identical to that of ANP.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
K. Sletten, P. Westermark, and J. B. Natvig, Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid, J. Exp. Med. 143:993 (1976).
P. Westermark, C. Wernstedt, E. Wilander, D. W. Hayden, T. D. O’Brien, and K. H. Johnson, Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a novel neuropeptide-like protein also present in normal islet cells, Proc. Natl. Acad. Sci. USA. 84:3881 (1987).
P. Westermark, B. Johansson, and J. B. Natvig, Senile cardiac amyloidosis: evidence of two different amyloid substances in the ageing heart, Scand. J. Immunol. 10:303 (1979).
G. G. Cornwell III, W. L. Murdoch, R. A. Kyle, P. Westermark, and P. Pitkänen, Frequency and distribution of senile cardiovascular amyloid. A clinicopathologic correlation, Am. J. Med. 75:618 (1983).
J. P. Henry, and J. W. Pearce, The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow, J. Physiol. (London) 131:572 (1956).
A. J. de Bold, H. B. Borenstein, A. T. Veress, and H. Sonnenberg, A rapid and potent natriuretic response to intravenous injection of atrial myocardial extracts in rats, Life Sci. 28:89 (1981).
S. Oikawa, M. Imai, A. Ueno, S. Tanaka, T. Noguchi, H. Nakazato, K. Kangawa, A. Fukuda, and H. Matsuo, Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide, Nature 309:724 (1984).
G. Thibault, R. Garcia, J. Gutkowska, J. Bilodeau, C. Lazure, N. G. Seidah, M. Chretien, J. Genest, and M. Cantin, The propeptide Asnl-Tyrl26 is the storage form of rat atrial natriuretic factor, Biochem. J. 241:265 (1987).
K. Kangawa, and H. Matsuo, Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP), Biochem. Biophys, Res. Commun. 118:131 (1984).
G. C. Kaye, M. G. Butler, A. J. D’Ardenne, S. J. Edmondson, A. J. Camm, and G. Slavin, Isolated atrial amyloid contains atrial natriuretic peptide: a report of six cases, Br. Heart J. 56:317 (1986).
B. Johansson, C. Wernstedt, and P. Westermark, Atrial natriuretic peptide deposited as atrial amyloid fibrils, Biochem. Biophys. Res. Commun, (in press).
P. Westermark, G. Cornwell III, B. Johansson, and J. B. Natvig, Senile cardiac amyloidosis, in: “Amyloid and Amyloidosis” G. G. Glenner, P. P. Costa, A. F. Freitas, eds. p. 217, Excerpta Medica, Amsterdam (1980).
F. E. Dische, C. Wernstedt, G. T. Westermark, P. Westermark, M. B. Pepys, J. A. Rennie, S. G. Gilbey, and P. J. Watkins, Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic, Submitted.
B. J. Ballerman, and B. M. Brenner, Role of atrial peptides in body fluid homeostasis, Circ. Res. 58:619 (1986).
R. E. Lang, H. Thölken, D. Ganten, F. C. Luft, H. Ruskoaho, and T. Unger, Atrial natriuretic factor — a circulating hormone stimulated by volume loading, Nature 314:264 (1985).
M. Nozuki, T. Mouri, K. Itoi, K. Takahasi, K. Totsune, T. Saito, and K. Yoshinaga, Plasma concentrations of atrial natriuretic peptide in various diseases, Tohoku J. Exp. Med. 148:439 (1986).
R. J. Cody, S. A. Atlas, J. H. Laragh, S. H. Kubo, A. B. Covit, K. S. Ryraan, A. Shaknovich, K. Pondolfino, M. Clark, M. J. F. Camargo, R. M. Scarborough, and J. A. Lewicki, Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion, J. Clin. Invest. 78:1362 (1986).
D. Roy, F. Paillard, D. Cassidy, M. G. Bourassa, J. Gutkowska, J. Genest, and M. Cantin, Atrial natriuretic factor during atrial fibrillation and supraventricular tachycardia, J. Am. Coll. Cardiol. 9:509 (1987).
L. M. Looi, Microscopical atrial amyloidosis in chronic heart diasease, Histopathology 5:615 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Science+Business Media New York
About this chapter
Cite this chapter
Johansson, B., Wernstedt, C., Westermark, P. (1988). Isolated Atrial Amyloid (IAA): A Cardiac Amyloid of Endocrine Origin. In: Isobe, T., Araki, S., Uchino, F., Kito, S., Tsubura, E. (eds) Amyloid and Amyloidosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0298-9_111
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0298-9_111
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0300-9
Online ISBN: 978-1-4757-0298-9
eBook Packages: Springer Book Archive