Isolated Atrial Amyloid (IAA): A Cardiac Amyloid of Endocrine Origin

  • B. Johansson
  • C. Wernstedt
  • P. Westermark


In the aging heart a localized amyloid restricted to the atria frequently occurs. This amyloid is designated isolated atrial amyloid (IAA). In the atria a natriuretic hormone, known as atrial natriuretic peptide (ANP), is produced. In this study, we show that antisera to IAA and to ANP both stain atrial muscle cells and atrial amyloid. Furthermore, a small protein purified from IAA had an amino acid sequence identical to that of ANP.


Amyloid Deposit Amyloid Fibril Atrial Natriuretic Factor Amino Acid Sequence Analysis Atrial Myocytes 
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  1. 1.
    K. Sletten, P. Westermark, and J. B. Natvig, Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid, J. Exp. Med. 143:993 (1976).CrossRefGoogle Scholar
  2. 2.
    P. Westermark, C. Wernstedt, E. Wilander, D. W. Hayden, T. D. O’Brien, and K. H. Johnson, Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a novel neuropeptide-like protein also present in normal islet cells, Proc. Natl. Acad. Sci. USA. 84:3881 (1987).CrossRefGoogle Scholar
  3. 3.
    P. Westermark, B. Johansson, and J. B. Natvig, Senile cardiac amyloidosis: evidence of two different amyloid substances in the ageing heart, Scand. J. Immunol. 10:303 (1979).CrossRefGoogle Scholar
  4. 4.
    G. G. Cornwell III, W. L. Murdoch, R. A. Kyle, P. Westermark, and P. Pitkänen, Frequency and distribution of senile cardiovascular amyloid. A clinicopathologic correlation, Am. J. Med. 75:618 (1983).CrossRefGoogle Scholar
  5. 5.
    J. P. Henry, and J. W. Pearce, The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow, J. Physiol. (London) 131:572 (1956).Google Scholar
  6. 6.
    A. J. de Bold, H. B. Borenstein, A. T. Veress, and H. Sonnenberg, A rapid and potent natriuretic response to intravenous injection of atrial myocardial extracts in rats, Life Sci. 28:89 (1981).CrossRefGoogle Scholar
  7. 7.
    S. Oikawa, M. Imai, A. Ueno, S. Tanaka, T. Noguchi, H. Nakazato, K. Kangawa, A. Fukuda, and H. Matsuo, Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide, Nature 309:724 (1984).CrossRefGoogle Scholar
  8. 8.
    G. Thibault, R. Garcia, J. Gutkowska, J. Bilodeau, C. Lazure, N. G. Seidah, M. Chretien, J. Genest, and M. Cantin, The propeptide Asnl-Tyrl26 is the storage form of rat atrial natriuretic factor, Biochem. J. 241:265 (1987).Google Scholar
  9. 9.
    K. Kangawa, and H. Matsuo, Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP), Biochem. Biophys, Res. Commun. 118:131 (1984).CrossRefGoogle Scholar
  10. 10.
    G. C. Kaye, M. G. Butler, A. J. D’Ardenne, S. J. Edmondson, A. J. Camm, and G. Slavin, Isolated atrial amyloid contains atrial natriuretic peptide: a report of six cases, Br. Heart J. 56:317 (1986).CrossRefGoogle Scholar
  11. 11.
    B. Johansson, C. Wernstedt, and P. Westermark, Atrial natriuretic peptide deposited as atrial amyloid fibrils, Biochem. Biophys. Res. Commun, (in press).Google Scholar
  12. 12.
    P. Westermark, G. Cornwell III, B. Johansson, and J. B. Natvig, Senile cardiac amyloidosis, in: “Amyloid and Amyloidosis” G. G. Glenner, P. P. Costa, A. F. Freitas, eds. p. 217, Excerpta Medica, Amsterdam (1980).Google Scholar
  13. 13.
    F. E. Dische, C. Wernstedt, G. T. Westermark, P. Westermark, M. B. Pepys, J. A. Rennie, S. G. Gilbey, and P. J. Watkins, Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic, Submitted.Google Scholar
  14. 14.
    B. J. Ballerman, and B. M. Brenner, Role of atrial peptides in body fluid homeostasis, Circ. Res. 58:619 (1986).CrossRefGoogle Scholar
  15. 15.
    R. E. Lang, H. Thölken, D. Ganten, F. C. Luft, H. Ruskoaho, and T. Unger, Atrial natriuretic factor — a circulating hormone stimulated by volume loading, Nature 314:264 (1985).CrossRefGoogle Scholar
  16. 16.
    M. Nozuki, T. Mouri, K. Itoi, K. Takahasi, K. Totsune, T. Saito, and K. Yoshinaga, Plasma concentrations of atrial natriuretic peptide in various diseases, Tohoku J. Exp. Med. 148:439 (1986).CrossRefGoogle Scholar
  17. 17.
    R. J. Cody, S. A. Atlas, J. H. Laragh, S. H. Kubo, A. B. Covit, K. S. Ryraan, A. Shaknovich, K. Pondolfino, M. Clark, M. J. F. Camargo, R. M. Scarborough, and J. A. Lewicki, Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion, J. Clin. Invest. 78:1362 (1986).CrossRefGoogle Scholar
  18. 18.
    D. Roy, F. Paillard, D. Cassidy, M. G. Bourassa, J. Gutkowska, J. Genest, and M. Cantin, Atrial natriuretic factor during atrial fibrillation and supraventricular tachycardia, J. Am. Coll. Cardiol. 9:509 (1987).CrossRefGoogle Scholar
  19. 19.
    L. M. Looi, Microscopical atrial amyloidosis in chronic heart diasease, Histopathology 5:615 (1981).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • B. Johansson
    • 1
  • C. Wernstedt
    • 2
  • P. Westermark
    • 1
  1. 1.Department of PathologyUniversity HospitalUppsalaSweden
  2. 2.Ludwig Institute of Cancer “Research Uppsala BranchUppsalaSweden

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