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Isolated Atrial Amyloid (IAA): A Cardiac Amyloid of Endocrine Origin

  • B. Johansson
  • C. Wernstedt
  • P. Westermark
Chapter

Abstract

In the aging heart a localized amyloid restricted to the atria frequently occurs. This amyloid is designated isolated atrial amyloid (IAA). In the atria a natriuretic hormone, known as atrial natriuretic peptide (ANP), is produced. In this study, we show that antisera to IAA and to ANP both stain atrial muscle cells and atrial amyloid. Furthermore, a small protein purified from IAA had an amino acid sequence identical to that of ANP.

Keywords

Amyloid Deposit Amyloid Fibril Atrial Natriuretic Factor Amino Acid Sequence Analysis Atrial Myocytes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • B. Johansson
    • 1
  • C. Wernstedt
    • 2
  • P. Westermark
    • 1
  1. 1.Department of PathologyUniversity HospitalUppsalaSweden
  2. 2.Ludwig Institute of Cancer “Research Uppsala BranchUppsalaSweden

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