Biochemical Characterization of Amyloid Protein in Primary Lichen Amyloidosis
Primary lichen amyloidosis is a form of localized cutaneous amyloidoses which is rather abundant skin disorder of people in the tropical and subtropical countries1. Although, histochemical and immunohistochemical observations with polyclonal and monoclonal antibodies have well been established, ethiology for this disorder is still left undetermined. However, several lines of approach recently made have shown that dermal amyloid seemed to be related to keratin derived from degenerated epidermal cells2,3.
We have previously reported primary sequence of several AL proteins of immunoglobulin origin and have discussed on the relationship between their primary structures and amyloidogenicity. The present paper describes some biochemical aspects on amyloid protein in primary lichen amyloidosis.
KeywordsAmyloid Protein Immunoglobulin Light Chain Analysis Amino Acid Composition Lichen Amyloidosis Cutaneous Amyloidosis
Unable to display preview. Download preview PDF.