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Biochemical Characterization of Amyloid Protein in Primary Lichen Amyloidosis

  • Tomotaka Shinoda
  • Tatsuyuki Takenawa
  • Fuyuki Kametani
  • Chu-K Wong
Chapter

Abstract

Primary lichen amyloidosis is a form of localized cutaneous amyloidoses which is rather abundant skin disorder of people in the tropical and subtropical countries1. Although, histochemical and immunohistochemical observations with polyclonal and monoclonal antibodies have well been established, ethiology for this disorder is still left undetermined. However, several lines of approach recently made have shown that dermal amyloid seemed to be related to keratin derived from degenerated epidermal cells2,3.

We have previously reported primary sequence of several AL proteins of immunoglobulin origin and have discussed on the relationship between their primary structures and amyloidogenicity. The present paper describes some biochemical aspects on amyloid protein in primary lichen amyloidosis.

Keywords

Amyloid Protein Immunoglobulin Light Chain Analysis Amino Acid Composition Lichen Amyloidosis Cutaneous Amyloidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Tomotaka Shinoda
    • 1
    • 2
  • Tatsuyuki Takenawa
    • 1
    • 2
  • Fuyuki Kametani
    • 1
    • 2
  • Chu-K Wong
    • 1
    • 2
  1. 1.Department of ChemistryTokyo Metropolitan UniversitySetaga-ku, Tokyo 158Japan
  2. 2.Veteran’s General HospitalTaipei, TaiwanJapan

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