Amyloid Fibril Protein in Finnish Hereditary Amyloidosis

  • C. P. J. Maury
  • A-M. Teppo
  • A-L. Kariniemi
  • A. H. Koeppen


Immunocytochemical methods were used to study the nature of the amyloid deposits in the Finnish form of familial amyloidosis, FAP type IV. Commercial antisera to human plasma transthyretin (prealbumin) did not stain the amyloid deposits, but positive staining was obtained with antibodies raised against transthyretin-related amyloid fibril whole protein. The amyloid deposits also stained with antiserum to serum amyloid P component, but did not stain with antisera to retinol-binding protein, amyloid A protein, γ-trace protein, β2-microglobulin, or immunoglobulin light chains. The serum level of serum transthyretin was significantly decreased in the Finnish FAP patients. The results suggest that the amyloid fibril protein in Finnish hereditary amyloidosis is related to transthyretin.


Amyloid Deposit Amyloid Fibril Cerebral Amyloid Angiopathy Corneal Dystrophy Immunoglobulin Light Chain 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • C. P. J. Maury
    • 1
    • 2
  • A-M. Teppo
    • 1
    • 2
  • A-L. Kariniemi
    • 1
    • 2
  • A. H. Koeppen
    • 1
    • 2
  1. 1.Fourth Department of Medicine and Department of DermatologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Neurology ServiceV.A. Medical CenterAlbanyUSA

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