Advertisement

New Adsorbents for Extracorporeal Removal of β2-Microglobulin

  • Shigeo Furuyoshi
  • Nobutaka Tani
  • Ryoichi Nakazawa
Chapter

Abstract

It has been reported that the amyloid deposition is frequently found at various tissues and organs in chronic hemodialysis patients,and this amyloid protein is homologous to β2-microglobulin (BMG)1. To prevent the progression of amyloid deposition, the direct removal of BMG from circulating blood has been tried using improved hemodialyzer. However, as the removal rate of BMG by dialyzer is still below the BMG production rate, serum BMG level can not be controlled as low as required for the regression or prevention. Therefore, it is desired that the device for more intensive BMG removal will be developed.

Keywords

Adsorption Rate Amyloid Deposition Circulation Time Blood Pump Amyloid Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    F. Gejyo, T. Yamada, S. Odani, Y. Nakagawa, M. Arakawa, T. Kunitomo, H. Kataoka, M. Suzuki, Y. Hirasawa, T. Shirahama, A. S. Cohen, and K. Schmid, A new form of amyloid protein associated with chronic hemodialysis was identified as β2-mcicroglobulin., Biochem. Biophys. Res. Commun., 129:701 (1985)CrossRefGoogle Scholar
  2. 2.
    F. A. Karlsson, T. Groth, K. Sege, L. Wibell, and P. A. Peterson, Turnover in humans β2-microglobulin: the constant chain of HLA antigens., Eur. J. Clin. Invest., 10:293 (1980).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Shigeo Furuyoshi
    • 1
  • Nobutaka Tani
    • 1
  • Ryoichi Nakazawa
    • 1
    • 2
  1. 1.Kanegafuchi Chemical IndustryCentral Research LaboratoriesKobeJapan
  2. 2.Sakura National HospitalSakuraJapan

Personalised recommendations