New Adsorbents for Extracorporeal Removal of β2-Microglobulin
It has been reported that the amyloid deposition is frequently found at various tissues and organs in chronic hemodialysis patients,and this amyloid protein is homologous to β2-microglobulin (BMG)1. To prevent the progression of amyloid deposition, the direct removal of BMG from circulating blood has been tried using improved hemodialyzer. However, as the removal rate of BMG by dialyzer is still below the BMG production rate, serum BMG level can not be controlled as low as required for the regression or prevention. Therefore, it is desired that the device for more intensive BMG removal will be developed.
KeywordsAdsorption Rate Amyloid Deposition Circulation Time Blood Pump Amyloid Protein
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- 1.F. Gejyo, T. Yamada, S. Odani, Y. Nakagawa, M. Arakawa, T. Kunitomo, H. Kataoka, M. Suzuki, Y. Hirasawa, T. Shirahama, A. S. Cohen, and K. Schmid, A new form of amyloid protein associated with chronic hemodialysis was identified as β2-mcicroglobulin., Biochem. Biophys. Res. Commun., 129:701 (1985)CrossRefGoogle Scholar