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Coexistence of B2-Microglobulin-Derived Amyloid Deposits and Ectopic Calcification in the Heart of a Chronic Hemodialysis Patient

  • Fumitake Gejyo
  • Noriyuki Homma
  • Hiroki Maruyama
  • Kazuhiko Ohara
  • Masaaki Arakawa
Chapter

Abstract

It has been clearly shown that a high proportion of patients who have been undergoing hemodialysis for ten or more years concurrently exhibit amyloidosis, which gives rise to osteoarticular diseases. Characteristic of these diseases is the carpal tunnel syndrome. The amyloidosis consistently increases as the period of hemodialysis lengthens. In a recent study involving biochemical analysis of amyloid nodules deposited in the periosteum of the carpus1,2, we established that the principal structural protein of the new type of amyloid of these nodules was β2-microglobulin(B2M). The question of whether the amyloidosis was localized in the bones and joints or had infiltrated into the parenchymatous internal organs was a matter of particular importance. The present paper reports a unique case showing calcification together with amyloid deposits in the heart, and describes the identification, when this case was autopsied, of the amyloid structure of the deposited protein as B2M.

Keywords

Carpal Tunnel Syndrome Amyloid Deposit Amyloid Fibril Chronic Hemodialysis Ectopic Calcification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    F. Gejyo, T. Yamada, S. Odani, et al., A new form of amyloid protein associated with chronic hemodialysis was identified as β2-microglobulin, Biochem. Biophys. Res. Commun. 129: 701 (1985).CrossRefGoogle Scholar
  2. 2.
    F. Gejyo, S. Odani, T. Yamada, et al., β2-microglobulin: A new form of amyloid protein associated with chronic hemodialysis, Kidney Int., 30: 385 (1986).CrossRefGoogle Scholar
  3. 3.
    T. Shirahama, M. Skinner, A. S. Cohen, et al., Histochemical and immunohistochemical characterization of amyloid associated with chronic hemodialysis as β2-microglobulin, Lab. Invest. 53:705 (1985).Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Fumitake Gejyo
    • 1
  • Noriyuki Homma
    • 1
  • Hiroki Maruyama
    • 1
  • Kazuhiko Ohara
    • 1
  • Masaaki Arakawa
    • 1
  1. 1.Department of Medicine(II)Niigata University School of MedicineNiigata 951Japan

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