Coexistence of B2-Microglobulin-Derived Amyloid Deposits and Ectopic Calcification in the Heart of a Chronic Hemodialysis Patient
It has been clearly shown that a high proportion of patients who have been undergoing hemodialysis for ten or more years concurrently exhibit amyloidosis, which gives rise to osteoarticular diseases. Characteristic of these diseases is the carpal tunnel syndrome. The amyloidosis consistently increases as the period of hemodialysis lengthens. In a recent study involving biochemical analysis of amyloid nodules deposited in the periosteum of the carpus1,2, we established that the principal structural protein of the new type of amyloid of these nodules was β2-microglobulin(B2M). The question of whether the amyloidosis was localized in the bones and joints or had infiltrated into the parenchymatous internal organs was a matter of particular importance. The present paper reports a unique case showing calcification together with amyloid deposits in the heart, and describes the identification, when this case was autopsied, of the amyloid structure of the deposited protein as B2M.
KeywordsCarpal Tunnel Syndrome Amyloid Deposit Amyloid Fibril Chronic Hemodialysis Ectopic Calcification
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- 3.T. Shirahama, M. Skinner, A. S. Cohen, et al., Histochemical and immunohistochemical characterization of amyloid associated with chronic hemodialysis as β2-microglobulin, Lab. Invest. 53:705 (1985).Google Scholar