Possibly “Familial” Cerebral Amyloid Angiopathy in Japan: Immunohistochemical Identification of Gamma-Trace

  • Shigeyoshi Fujihara
  • Koichi Shimode
  • Shotai Kobayashi
  • Tokugoro Tsunematsu


Cerebral amyloid angiopathy is one of the aging processes of the brain, that has been reported to cause recurrent cerebral hemorrhage1, and is attracting attention as an important pathological changes of Alzheimer disease2. Hereditary forms of cerebral amyloid angiopathy manifested with repeated cerebral hemorrhage in young adults has been reported as hereditary cerebral hemorrhage with amyloidosis ( HCHWA ) in Iceland3. A γ-trace variant protein has been reported as the maior constituent of the amyloid fibrils in patients from Iceland with HCHWA4. Similar families have been reported only from Netherlands as familial cerebral amyloid angiopathy5.


Senile Plaque Cerebral Hemorrhage Amyloid Fibril Cerebral Amyloid Angiopathy Familial Amyloidotic Polyneuropathy10 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Shigeyoshi Fujihara
    • 1
  • Koichi Shimode
    • 1
  • Shotai Kobayashi
    • 1
  • Tokugoro Tsunematsu
    • 1
  1. 1.3rd Division of Internal MedicineShimane Medical UniversityIzumo 693Japan

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