Possibly “Familial” Cerebral Amyloid Angiopathy in Japan: Immunohistochemical Identification of Gamma-Trace
Cerebral amyloid angiopathy is one of the aging processes of the brain, that has been reported to cause recurrent cerebral hemorrhage1, and is attracting attention as an important pathological changes of Alzheimer disease2. Hereditary forms of cerebral amyloid angiopathy manifested with repeated cerebral hemorrhage in young adults has been reported as hereditary cerebral hemorrhage with amyloidosis ( HCHWA ) in Iceland3. A γ-trace variant protein has been reported as the maior constituent of the amyloid fibrils in patients from Iceland with HCHWA4. Similar families have been reported only from Netherlands as familial cerebral amyloid angiopathy5.
KeywordsSenile Plaque Cerebral Hemorrhage Amyloid Fibril Cerebral Amyloid Angiopathy Familial Amyloidotic Polyneuropathy10
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- 2.G. G. Glenner, J. H. Henry, S. Fujihara, Congophilic angiopathy in the pathogenesis of Alzheimer’s degeneration. Ann. Pathol. 1:120 (1981).Google Scholar
- 7.A. Grubb and H. Lofberg, Human γ-trace. structure, function and clinical use of concentration measurements. Scand. J. Clin. Lab. Invest. 45, Suppl. 177:7 (1985)Google Scholar
- 8.S. Fujihara, J. E. Balow, J. C. Costa, G. G. Glenner, Identification and Classification of amyloid in formal in-fixed,paraffin-embedded tissue sections by the unlabeled immunoperoxidase method. Lab. Invest. 43:358 (1980).Google Scholar
- 9.S. Fujihara, G. G. Glenner, Primary localized amyloidosis of the genito-urinary tract:Immunohistochemical study on eleven cases. Lab. Invest. 44:55 (1981).Google Scholar
- 13.H. Löfberg, A. O. Grubb, E. K. Nilsson, O. Jensson, G. Gudmundsson, H. Blondal, A. Arnason, L. Thorsteinsson, Immunohistochemical characterization of the amyloid deposits and quantitation of pertinent cerebrospinal fluid proteins in hereditary cerebral hemorrhage with amyloidosis. Stroke 18:431 (1987).CrossRefGoogle Scholar