apoSAA and AA: Precursor and Product Revisited

  • C. Tape
  • R. Tan
  • M. Nesheim
  • R. Kisilevsky


Since the discovery of the immunologie cross-reactivity and amino acid sequence identity between AA amyloid and the amino terminal portion of apoSAA, a precursor-product relationship between these two proteins has been envisaged (1). In light of the chronically elevated level of serum apoSAA requisite for the development of AA amyloidosis, the role of precursor to deposited AA has been ascribed to the circulating apoSAA pool. The selective removal of the putative amyloid-forming isotype apoSAA2 from the circulation of amyloidotic mice provides indirect support for this hypothesis (2), Other than a single report of the apparent conversion of human apoSAA to human AA in mice (3), direct evidence of a precursor product relationship has been lacking.


Amino Acid Sequence Identity Pekin Duck Initial Specific Activity Formic Acid Extract Amyloid Enhance Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kisilevsky, R. Am. J. Path. vn49:381–390, 1983.Google Scholar
  2. 2.
    Meek, R., Hoffman, J.S., Benditt, E.P. J. Exp. Med. 163:499–510, 1986.CrossRefGoogle Scholar
  3. 3.
    Husebekk, A., Skogen, B., Husby, G., Marhaug, G. Scand. J. Immunol. 21:283–287, 1985.CrossRefGoogle Scholar
  4. 4.
    Baltz, M.L., Rowe, I.F., Caspi, D., Turneil, W.G., Pepys, M.B. Clin. Exp. Immunol. 66:701–708, 1986.Google Scholar
  5. 5.
    Kisilevsky, R., Weiler, L., Treloar, M.A. J. Biol. Chem. 253:7010–7108, 1978.Google Scholar
  6. 6.
    Kisilevsky, R., Boudreau, L. Am. J. Path. vn48:53–59, 1983.Google Scholar
  7. 7.
    Sipe, J.D. Ignaczak, T.F., Pollock, P.S., Glenner, C.G. J. Immunol. 116:1151–1156, 1976.Google Scholar
  8. 8.
    Glenner, G.G., Terry, W., Harada, M., Isersky, C, Page, D. Science 172:1150–1151, 1971.CrossRefGoogle Scholar
  9. 9.
    Ramadori, G., Sipe, J.D., Colten, H.R. J. Immunol. 135:3645–3647, 1985.Google Scholar
  10. 10.
    Meek, R., Benditt, E.P. J. Exp. Med. 164:2006–2017, 1986.CrossRefGoogle Scholar
  11. 11.
    Westermark, P., Sletten, K. Clin. Exp. Immunol. 49:725–731, 1982.Google Scholar
  12. 12.
    Ericsson, L.H., Eriksen, N., Walsh, K.A., Benditt, E.P. FEBS Lett. 218:11–16, 1987.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • C. Tape
    • 1
  • R. Tan
    • 1
  • M. Nesheim
    • 1
  • R. Kisilevsky
    • 1
  1. 1.Department of Pathology and BiochemistryQueen’s University and Kingston General HospitalKingstonCanada

Personalised recommendations