Intracellular Pathways; Exocytic and Endocytic Routes Relying upon Selective Vesicular Transport
For hydrophilic macromolecules to be transported into cells and across tissue barriers the major permeability barriers are the lipid bilayers of the continuous membrane boundaries which surround and compartmentalise all eukaryotic cells. Specialised mechanisms within these boundaries can translocate relatively large molecular species such as polypeptides across the hydrophobic internum of the bilayer but these mechanisms provide major routes of access only into biosynthetic compartments such as the rough endoplasmic reticulum (RER).
KeywordsSecretory Granule Cytoplasmic Domain Rough Endoplasmic Reticulum Transferrin Receptor Late Endosome
Unable to display preview. Download preview PDF.
- Caplan, M.J., H.C. Anderson, G.E. Palade, and J.D. Jamieson. (1986). Intracellular sorting and polarized cell surface delivery of (Na+-K+) — ATPase, an endogenous component of MDCK cell basolateral plasma membranes. Cell. 24: 24–32.Google Scholar
- Fujita, M., F. Reinhart, and M. Neutra. (1988). Convergence of apical and basolateral endocytic pathways at the late endosome; double tracer studies in ileal absorptive cells of suckling rats. J. Cell Biol. 107: Abtr. 616.Google Scholar
- Hopkins, C.R. (1986). Membrane boundaries involved in the uptake and intracellular processing of cell surface receptors. TIBS. 11: 473–477.Google Scholar
- Kirchausen, T., K.L. Nathanson, W. Matsui, A. Vaisberg, E.P. Chow, C. Burne, J. Keen, J. Hand, and A.E. Davis. (1989). Structural and functional division into two domains of the large (100-to 115-kDa)) chains of the clathrin-associated protein complex AP-2. Proc. Natl. Acad. Sci. USA. 86: 2612–2616.CrossRefGoogle Scholar
- Snider, M., and O.C. Rogers. (1986). Membrane traffic in animal cells: cellular glycoproteins return to the site of Golgi mannosidase 1. J. Cell. Physiol. 115: 199–207.Google Scholar