Use of Fabricated Living Tissue and Organ Equivalents as Defined Higher Order Systems for the Study of Pharmacologic Responses to Test Substances
Because animal tissues resemble human tissues, the use of animals as model systems in pharmacologic studies was a natural outcome of laboratory practice. But with the realization that there are significant differences between animal skin and human skin and between responses given by animals as compared with humans,1,2,3 to substances that come into contact with the skin or tissues of the eye, and because of humane considerations, there has developed a major move away from the use of animals toward alternatives to animal testing.
KeywordsBenzoic Acid Stratum Corneum Test Substance Collagen Biosynthesis Minimal Erythemic Dose
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