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In Vitro Evaluation of Macrophage Mediated Host Defenses against Neoplastic Disease

  • R. Kirsh
  • P. J. Bugelski
Part of the NATO ASI Series book series (NSSA, volume 218)

Abstract

The ability of malignant tumors to disseminate to organs distant from the site of the primary lesions is the principal reason for failure in cancer therapy.(1) There are several reasons for this high failure rate. First, at the time of initial diagnosis, metastatic lesions may be too small to detect using currently available diagnostic methodologies; second, the anatomic location of the metastatic lesion may limit the dose of antineoplastic drug that can reach the site without excessive toxicity; and third, the heterogeniety of tumor cell phenotypes within a single lesion is sufficiently diverse, that the responsiveness of cells from one lesion to an antineoplastic modality can differ from both the primary lesion and other metastases.(2–4) This latter issue suggests that the development of an effective therapy for metastatic disease approaches that will circumvent the problems of cellular heterogenicity.

Keywords

Alveolar Macrophage Human Monocyte Macrophage Activation Mouse Macrophage Macrophage Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • R. Kirsh
    • 1
  • P. J. Bugelski
    • 2
  1. 1.Departments of Drug DeliverySmithKline & French LaboratoriesKing of PrussiaUSA
  2. 2.Experimental PathologySmithKline & French LaboratoriesKing of PrussiaUSA

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