Regulation of Haemopoietic Cell Development

  • Nydia G. Testa
  • Thomas M. Dexter
  • Terence D. Allen
Part of the NATO ASI Series book series (NSSA, volume 218)


The constant supply of blood cells required to maintain a normal steady state by replacing the cells lost through senescence is of the order of 4 × 10″ cells per day in a normal human adult, and is even larger in response to haemopoietic stress like blood loss or infection. All blood cells are derived from stem cells in the bone marrow tissue in the adult. The stem cells are characterized by a) their capacity to reconstitute the haemopoietic system of individuals who had received a potentially lethal dose of irradiation, b) their capacity of self-renewal by which they can regenerate their own population after serious and repeated depletion caused by cytotoxic injury, and c) their multipotentiality, i.e. they give rise to all the myeloid and lymphoid cell types.


Autologous Bone Marrow Adherent Layer Culture Bone Marrow Cell Bone Marrow Tissue Haemopoietic Cell 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Nydia G. Testa
    • 1
  • Thomas M. Dexter
    • 1
  • Terence D. Allen
    • 1
  1. 1.Paterson Institute for Cancer ResearchChristie Hospital & Holt Radium InstituteManchesterUK

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