Experimental Models for Buccal and Sublingual Drug Absorption Including Epithelial Cell Multilayers and Monolayers
Like the skin the oral mucosa is constantly exposed to the environment thus its fundamental property is probably a barrier function. Pathogens and other potentially harmful materials, which may be borne in air, water or food, are excluded by the stratified epithelial cell layers, which seem to be more closely related to skin than to the columnar epithelia of the gastrointestinal tract (Squier and Johnson, 1975). Thus while the barrier properties are important in the resistance of disease they may also compromise potential drug absorption via the buccal or sublingual routes.
KeywordsBuccal Mucosa Madin Darby Canine Kidney Lipophilic Drug Transepithelial Electrical Resistance Madin Darby Canine Kidney Cell
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