Regulation of the Myocardial Blood Supply by Adenosine and Adenine Nucleotides: Consequences of Newly Detected Barrier Functions of the Coronary Endothelium
In the classical physiological view coronary flow is regulated mainly by certain metabolic products that are liberated by the cardiomyocytes, in amounts that increase with increasing cardiac work-load. Like chemical transmitters, these products are thought to develop their dilatory action directly at smooth muscle cells of the coronary resistance vessels. Adenosine, which is mainly derived by stepwise dephosphorylation of the central energy carrier of the myocardial metabolism, 5′-ATP, is still considered to be the most important mediator substance of this metabolic regulation of coronary flow (1) (fig 1).
KeywordsCoronary Flow Adenine Nucleotide Percoll Gradient Coronary System Coronary Endothelial Cell
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