Abstract
The transport rate across the BBB is an essential kinetic parameter for drugs acting on the central nervous system, because it determines the time to onset and the intensity of drug action.1,2 For the study of BBB-passage in vivo, various models have been described, however most techniques require the use of many experimental animals and offer only limited information.3–5 Moreover, in the in vivo situation the estimated transport parameters are inevitably influenced by physiological factors which cannot be kept under control during the experiment (e.g. cerebral blood flow, hormone levels, stress levels).6 Therefore comparison of BBB transport parameters obtained in different experimental settings is hazardous.
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© 1991 Plenum Press, New York
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van Bree, J.B.M.M., de Boer, A.G., Danhof, M., Breimer, D.D. (1991). Transport of Drugs Across the Blood-Brain Barrier: In Vitro and in Vivo Strategies. In: Wilson, G., Davis, S.S., Illum, L., Zweibaum, A. (eds) Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport. NATO ASI Series, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0286-6_14
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DOI: https://doi.org/10.1007/978-1-4757-0286-6_14
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